As a powerful synthetic tool for the formation of aromatic C−N bonds, the reported transition-metalcatalyzed direct C−H amination has been ineffective for the synthesis of triarylamines for a long time. Herein, an elegant strategy for the preparation of triarylamines was disclosed using inexpensive Co(OAc) 2 •4H 2 O as the catalyst. It is noteworthy that unactivated arenes and simple anilines were employed as the starting materials with good functional group tolerance. In addition, an organometallic Co(III) species was isolated and identified by X-ray crystallography, thus providing some in-depth insights into the mechanism.
A cobalt-catalyzed C(sp2)–H alkoxylation of 1-naphthylamine derivatives has been disclosed, which represents an efficient approach to synthesize aryl ethers with broad functional group tolerance. It is noteworthy that secondary alcohols, such as hexafluoroisopropanol, isopropanol, isobutanol, and isopentanol, were well tolerated under the current catalytic system. Moreover, a series of biologically relevant fluorine-aryl ethers were easily obtained under mild reaction conditions after the removal of the directing group.
Inexpensive Mn(ii)-catalyzed cascade annulations with air as the green oxidant were reported, enabling the facile preparation of isoquinolin-1(2H)-one scaffolds.
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