The preparation of hydrogels for wound healing properties with high antibacterial activities and good biosafety concurrently can be relatively challenging. For addressing these issues, we report on the synthesis and characterisation of a nanocomposite hydrogel dressing by introducing the silver nanoparticles in hydroxypropyl methylcellulose‐hydroxyapatite scaffold hydrogel (HMC‐HA/AgNPs). The different concentrations of AgNPs in HMC‐HA/AgNPs hydrogels were confirmed by swelling ratio, degradation, and gelatin time. The synthesised HMC‐HA/AgNPs hydrogels were further characterised using the UV‐visible, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectrum, and X‐ray diffraction. The results showed that the novel HMC‐HA/AgNPs hydrogel exhibited a porous 3D network and high mechanical properties because of the inter‐molecular and intra‐molecular interactions. The AgNPs give the HMC‐HA hydrogels excellent antibacterial activities against both Staphylococcus aureus and Escherichia coli, without any chemical reductant and cross‐linking agent required endows the hydrogel high biocompatibility. More importantly, HMC‐HA/AgNPs effectively repaired wound defects in mice models, and wound healing reached 94.5 ± 1.4% within 16 days. The HMC‐HA hydrogel with AgNPs showed excellent antimicrobial activity and burn wound healing. Therefore, these HMC‐HA/AgNPs hydrogels have great potential as an injectable hydrogel for wound healing activity in children with burn injuries.
Currently, the synthesis of silver nanoparticles (AgNPs) was utilized for various life-saving biomedical applications. Herein, we report the synthesis and characterization of methylcellulose and hyaluronic acid (MC-HA) hydrogels containing AgNPs dressing materials were investigated for their wound healing efficiency to treat surgical excision wounds and the findings were studied and discussed. The effect of the ratio of AgNPs and MC-HA hydrogels on the gelation time, in vitro degradation, and equilibrium swelling of MC-HA/AgNPs hydrogels was examined. The prepared MC-HA hydrogels containing AgNPs were studied using various characterization techniques such as UV–Visible spectroscopy, Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD). The MC-HA/AgNPs showed excellent antimicrobial activity against S. aureus and E. coli, respectively. Additionally, the superior wound recovering potential of AgNPs with MC-HA hydrogels compared to conventional formulations was illustrated in vitro in animals utilizing visual observations and histological study. The MC-HA/AgNPs hydrogels showed excellent antimicrobial activity and burn wound healing. Therefore, these MC-HA hydrogels containing AgNPs have great potential medicinal applications in nursing care in children after surgery.
We conducted a meta-analysis to assess the effect of endoscopic submucosal dissection compared with gastrectomy on the wound infection in early stomach cancer subjects. A systematic literature search up to November 2022 was performed and 2765 related studies were evaluated. The chosen studies comprised 7842 early stomach cancer subjects participated in the selected studies' baseline trials; 3308 of them used the endoscopic submucosal dissection, while 4534 used gastrectomy. Odds ratio (OR) with 95% confidence intervals (CIs) were calculated to assess the wound infection in endoscopic submucosal dissection versus gastrectomy for early stomach cancer by the dichotomous methods with a random or fixed effect model. The use of endoscopic submucosal dissection resulted in significantly lower wound infection (OR, 0.45; 95% CI, 0.34-0.60, P < .001) with no heterogeneity (I 2 = 8%) compared with the gastrectomy for early stomach cancer. The use of endoscopic submucosal dissection resulted in significantly lower wound infection compared with the gastrectomy for early stomach cancer. The small sample size of some studies in the comparison calls for care when analysing the results.
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