The preparation of hydrogels for wound healing properties with high antibacterial activities and good biosafety concurrently can be relatively challenging. For addressing these issues, we report on the synthesis and characterisation of a nanocomposite hydrogel dressing by introducing the silver nanoparticles in hydroxypropyl methylcellulose‐hydroxyapatite scaffold hydrogel (HMC‐HA/AgNPs). The different concentrations of AgNPs in HMC‐HA/AgNPs hydrogels were confirmed by swelling ratio, degradation, and gelatin time. The synthesised HMC‐HA/AgNPs hydrogels were further characterised using the UV‐visible, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectrum, and X‐ray diffraction. The results showed that the novel HMC‐HA/AgNPs hydrogel exhibited a porous 3D network and high mechanical properties because of the inter‐molecular and intra‐molecular interactions. The AgNPs give the HMC‐HA hydrogels excellent antibacterial activities against both Staphylococcus aureus and Escherichia coli, without any chemical reductant and cross‐linking agent required endows the hydrogel high biocompatibility. More importantly, HMC‐HA/AgNPs effectively repaired wound defects in mice models, and wound healing reached 94.5 ± 1.4% within 16 days. The HMC‐HA hydrogel with AgNPs showed excellent antimicrobial activity and burn wound healing. Therefore, these HMC‐HA/AgNPs hydrogels have great potential as an injectable hydrogel for wound healing activity in children with burn injuries.
Thin film organic field-effect transistors (OFETs) are usually featured with charge traps, limiting charge transport and leading to low mobility especially at low gate voltages. In this work, doping process of a model organic semiconductor 2,7-didodecyl[1]benzothieno [3,2-b][1]benzothiophene (C12-BTBT) has been manipulated, using low-cost reactive oxygen namely oxygen plasma or ozone. It is found that low-pressure (20 Pa) oxygen plasma can induce a low-moderate doping concentration, which is, however, sufficient to warrant field-effect mobilities over 5 cm 2 V À1 s À1 in a large gate voltage range and sharp subthreshold swings, without degradation of on/off ratio. Lowpressure oxygen plasma can also positively shift the threshold voltage of the device, thus largely reducing the working voltages. Oxygen plasma with higher pressure than 100 Pa induces higher doping concentration, more significantly shifting the threshold voltage and deteriorating on/off ratio due to substantial bulk electrical conductivity, which is similar to the treatment by UV-ozone at atmospheric pressure. As compared with the well-studied organic dopant F4-TCNQ, the doping process of reactive oxygen can be more easily in situ manipulated to reach an appropriate range of doping concentration, warranting higher performance and larger tunability for OFETs.
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