Nickel‐rich layered oxide LiNi0.8Mn0.1Co0.1O2 became one of the preferred cathode materials for lithium‐ion batteries because of its advantages in capacity, cost and environmental protection. However, increased nickel content inevitably leads to more serious structural deterioration, such as irreversible phase transition, unexpected side effects as well as Li+/Ni2+ mixing, etc. This results in poor cycle stability and rate performance. Herein, we proposed a co‐modification strategy for Mg doping and LiFePO4 coating to enhance the aforementioned electrochemical performance of LiNi0.8Co0.1Mn0.1O2. The results indicated that Mg0.02‐NCM@20LFP exhibited lower surface film resistance and charge transfer resistance than pristine material after 200 cycles at 1C. A cycle retention rate of 90.8 % can still be maintained after 100 cycles at 0.2C. When returning to 0.1C after 5C high magnification, 98 % of the capacity can be recovered, showing that the material has good structural integrity.
Abnormal cerebral accumulation of amyloid-beta peptide (Aβ) is a major hallmark of Alzheimer’s disease. Non-invasive monitoring of Aβ deposits enables assessing the disease burden in patients and animal models mimicking aspects of the human disease as well as evaluating the efficacy of Aβ-modulating therapies. Previous in vivo assessments of plaque load have been predominantly based on macroscopic fluorescence reflectance imaging (FRI) and confocal or two-photon microscopy using Aβ-specific imaging agents. However, the former method lacks depth resolution, whereas the latter is restricted by the limited field of view preventing a full coverage of the large brain region. Here, we utilized a fluorescence molecular tomography (FMT)-magnetic resonance imaging (MRI) pipeline with the curcumin derivative fluorescent probe CRANAD-2 to achieve full 3D brain coverage for detecting Aβ accumulation in the arcAβ mouse model of cerebral amyloidosis. A homebuilt FMT system was used for data acquisition, whereas a customized software platform enabled the integration of MRI-derived anatomical information as prior information for FMT image reconstruction. The results obtained from the FMT-MRI study were compared to those from conventional planar FRI recorded under similar physiological conditions, yielding comparable time courses of the fluorescence intensity following intravenous injection of CRANAD-2 in a region-of-interest comprising the brain. In conclusion, we have demonstrated the feasibility of visualizing Aβ deposition in 3D using a multimodal FMT-MRI strategy. This hybrid imaging method provides complementary anatomical, physiological and molecular information, thereby enabling the detailed characterization of the disease status in arcAβ mouse models, which can also facilitate monitoring the efficacy of putative treatments targeting Aβ.
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