This investigation explores the feasibility of a catheter-based receiver probe for NMR study of arterial walls. Simulations and phantom experiments demonstrate the spatial response of several "inside-out" probe coil designs, including loop, "birdcage," "multipole," "center return," and opposed solenoids. For a target defined by an annulus in a plane perpendicular to B0, the opposed solenoid design provides substantially superior homogeneity to other designs considered. Canine iliofemoral artery images were acquired using a catheter probe in a whole-body, 1.5-T clinical imaging system. In situ (cadaver) images acquired with TE 70, TR 2400, 2-mm slice thickness, and 78 x 78-microns in-plane voxel size in 10-min acquisition times show vessel wall structures identified as intima, internal elastic lamina, media, and adventitia. In vivo images from similar acquistion conditions are much more poorly resolved, presumably due to motion, despite the use of cardiac gating and gradient moment nulling, so the feasibility of obtaining high-resolution in vivo MR images of the arterial wall remains in doubt.
These data suggest that MRI is as good as MRS to quantify liver fat content. Our data also suggest that liver fat content could link intraabdominal fat with insulin resistance and dyslipidaemia.
Three methods of performing magnetization transfer (MT) MR imaging are analyzed: (a) off-resonance continuous wave, (b) off-resonance shaped pulses, and (c) on-resonance binomial pulses. With two-pool Bloch-model simulations, signal levels from "MT active" spin systems were calculated, with reference to direct saturation of "MT inactive" systems, allowing calculation of contrast due to MT. Simulations demonstrate several trends with variation of excitation amplitude and offset frequency for the off-resonance methods and with variation of excitation amplitude and pulse shape "order" for binomial pulses. The simulations show that nominally optimized versions of each of these approaches provide essentially equivalent contrast at a given level of applied MT power, contrary to previous claims. Experiments with an MT-inactive phantom, with a whole-body system, show results with off-resonance pulses to be in good agreement with simulations, whereas binomial-pulse experiments show anomalously large direct saturation.
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