Highlights d Recoding of two nucleotides in FOXO3 gene is sufficient to activate FOXO3 activity d Genetic activation of FOXO3 reinforces the homeostasis of human vascular cells d FOXO3-enhanced vascular cells promote revascularization after ischemic surgery d FOXO3-activated human stem cells are resistant to oncogenic transformation
Highlights d CBX4 is downregulated in physiologically and pathologically aged hMSCs d CBX4 deficiency leads to premature cellular senescence in hMSCs d CBX4 counteracts hMSC senescence by maintaining nucleolar homeostasis d CBX4 overexpression alleviates cellular senescence and osteoarthritis
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