Background
cranial nerve (CN) palsy in nasopharyngeal carcinoma with cancer-related involvement of cranial nerve has been considered as an unfavorable prognostic factor for NPC. We assessed the role of IMRT based treatment modality on the recovery of CN and investigated the prognostic value of CN palsy recovery.
Methods
A total of 115 NPC patients with CN palsy were included in the study. We referred CTCAE version 5.0 to evaluate the grade of CN palsy.
Results
All patients with grade 1 CN palsy recovered completely during the 2 years of follow-up after definite treatment. Most grade 2 palsy could change gradually to grade 1 palsy or complete recovery during two years of follow-up. The 3-year DFS were 84.9% in patients experienced 1 or 2 symptom of CN palsy compared with 60.3% in patients with more than 2 symptoms of CN palsy (HR: 0.25, 95%CI: 0.07–0.89, P = 0.001).
Conclusions
IMRT based comprehensive treatment could effectively promote the recovery of tumor-related CN palsy in locoregionally advanced NPC.
Microfluidic technology is a science and technology that can accurately
manipulate fluids in micro-sized channels. In recent years, microfluidic
devices have attracted wide attention due to its easy manipulation,
miniaturized size, high throughput and precise control, which provide a
potential platform for antibody screening. This review paper provides an
overview of recent advances in microfluidic methods application in the
field of antibody preparation. While hybridoma technology and four
antibody engineering techniques including phage display, single B cell
antibody screening, antibody expression and cell-free protein synthesis
are mainly introduced, important advances of experimental models and
results are also discussed. Furthermore, the authors expound on the
limitations of current microfluidic screening system and present future
directions of antibody screening platform based on microfluidics.
Antibody preparation on microfluidics combined with other technologies
has huge application potential in the field of biomedicine, and it is
anticipated to be further developed.
Based on the rainfall data from 197 rain gauge stations for the period
1960 to 2019, linear regression, moving average, and SURFER spatial
analysis were used to analyze the temporal and spatial characteristics
of rainfall in the Beijing-Tianjin-Hebei region, and compare the
difference in rainfall between the mountainous areas and plains, during
the flood season. The results show that (1) the overall duration of
rainfall in each region of Beijing-Tianjin-Hebei exhibit a downward
trend, and the overall spatial performance gradually decreases from east
to west. (2) The mountainous areas in the Beijing-Tianjin-Hebei region
are prone to light and moderate rainfall events; the plains are more
prone to rainfall events at levels above moderate rain, especially
rainstorms and heavy rain events; the probability of light and moderate
rainfall events in the suburbs is close to that of the urban areas, but
the probability of rainfall events at levels above heavy rain is less
than that of the urban areas; the probability of rainfall events of all
levels in the outer suburbs is higher. (3) Increase in rainfall in urban
areas compared to the southern suburbs is greater than when compared
with the northern suburbs which are at different stages of urbanization,
but the effect of urbanization on rainfall is also reflected in the
comparison between the urban areas and the northern suburbs. (4) With
increasing urbanization, the built environment in the mountainous areas
and plains of the Beijing-Tianjin-Hebei region has continued to grow,
and the original underlying surface conditions have changed. Because the
urbanization process is faster in the urban areas than in the suburbs,
the changes to the underlying surface conditions lead to greater
increase in rainfall in urban areas during the flood season compared to
the suburbs; the urban areas are also more prone to rainfall events at
levels above heav
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