An electrooxidative direct arylsulfonlylation of ynones with sulfinic acids via a radical tandem cyclization strategy has been developed for the construction of sulfonated indenones under oxidant-free conditions. This method provides a simple and efficient approach to prepare various sulfonylindenones in good to excellent yields, demonstrating the tremendous prospect of utilizing electrocatalysis in oxidative coupling. Notably, this reaction could be easily scaled up with good efficiency.
The first copper-catalyzed oxysulfonylation reaction of alkenes with dioxygen and sulfonylhydrazides for the construction of β-ketosulfones has been developed under mild conditions without any ligand or additive.
A simple and convenient approach for the construction of β-iodovinyl sulfones has been developed via direct difunctionalization of alkynes with sulfinic acids and molecular iodine.
A biomimetic photocatalyst of single-atom iron site (CNH) has been initially fabricated through coupling carbon nitride with hemin for the visible light-promoted sulfonation of alkenes to access β-ketosulfones.
A novel and direct oxidative spirocyclization of arylpropiolamides with sulfonylhydrazides leading to 3-sulfonated azaspiro[4,5]trienones has been developed under metal-free conditions. The reaction is performed in a tandem manner constituted by the sequential sulfonylation of alkynes, ipso-carbocyclization, dearomatization, hydration, and oxidation processes, providing a convenient and efficient approach to various sulfonated azaspiro[4,5] trienones of biological importance.
A catalysis-based, label-free, and high-throughput colorimetric protocol has been initially proposed for detecting mercury(II) in blood and wastewater with 96-cell plates, based on the mercury-enhanced catalytic activity of small silver nanoparticles synthesized in a gelatin matrix with unique temperature switchable sol-gel transition.
A novel Cu-catalyzed direct hydrosulfonylation of alkynes with arylsulfinic acids for the synthesis of (E)-vinyl sulfones has been realized under mild conditions with 100% atom efficiency. The present protocol provides an attractive approach to various vinyl sulfones in good to excellent yields, with the advantages of operation simplicity, atom economy, and high stereo- and regioselectivities.
Electrochemical-induced
transfer hydrogenation (TH) of N-heteroaromatic
to construct biologically active functional molecule is an appealing
and yet challenging task. We report herein the first selective transfer
hydrogenation of imidazopyridine derivatives with secondary amines
as the hydrogen donors under electrochemical conditions. The successful
conversion of cathode transfer hydrogenation depends on the solvation
effect. Importantly, such electrochemical-induced transfer hydrogenation
can be easily amplified with excellent efficiency.
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