The unique physicochemical properties of two-dimensional (2D) graphene oxide (GO) could greatly benefit the biomedical field; however, recent research demonstrated that GO could induce in vitro and in vivo toxicity. We determined the mechanism of GO induced toxicity, and our in vitro experiments revealed that pristine GO could impair cell membrane integrity and functions including regulation of membrane- and cytoskeleton-associated genes, membrane permeability, fluidity and ion channels. Furthermore, GO induced platelet depletion, pro-inflammatory response and pathological changes of lung and liver in mice. To improve the biocompatibility of pristine GO, we prepared a series of GO derivatives including aminated GO (GO-NH2), poly(acrylamide)-functionalized GO (GO-PAM), poly(acrylic acid)-functionalized GO (GO-PAA) and poly(ethylene glycol)-functionalized GO (GO-PEG), and compared their toxicity with pristine GO in vitro and in vivo. Among these GO derivatives, GO-PEG and GO-PAA induced less toxicity than pristine GO, and GO-PAA was the most biocompatible one in vitro and in vivo. The differences in biocompatibility were due to the differential compositions of protein corona, especially immunoglobulin G (IgG), formed on their surfaces that determine their cell membrane interaction and cellular uptake, the extent of platelet depletion in blood, thrombus formation under short-term exposure and the pro-inflammatory effects under long-term exposure. Overall, our combined data delineated the key molecular mechanisms underlying the in vivo and in vitro biological behaviors and toxicity of pristine GO, and identified a safer GO derivative that could be used for future applications.

We demonstrate a compact Q-switched dual-wavelength erbium-doped fiber (EDF) laser based on graphene as a saturable absorber (SA). By optically driven deposition of graphene on a fiber core, the SA is constructed and inserted into a diode-pumped EDF laser cavity. Also benefiting from the strong third-order optical nonlinearity of graphene to suppress the mode competition of EDF, a stable dual-wavelength Q-switching operation has been achieved using a two-reflection peak fiber Bragg grating as the external cavity mirror. The Q-switched EDF laser has a low pump threshold of 6.5 mW at 974 nm and a wide range of pulse-repetition rate from 3.3 to 65.9 kHz. The pulse duration and the pulse energy have been characterized. This is, to the best of our knowledge, the first demonstration of a graphene-based Q-switched laser.

Passive Q-switching of an ytterbium-doped fiber (YDF) laser with few-layer topological insulator (TI) is, to the best of our knowledge, experimentally demonstrated for the first time. The few-layer TI: Bi 2 Se 3 (2-4 layer thickness) is fabricated by the liquid-phase exfoliation method, and has a low saturable optical intensity of 53 MW/cm 2 measured by the Z-scan technique. The optical deposition technique is used to induce the few-layer TI in the solution onto a fiber ferrule for successfully constructing the fiber-integrated TI-based saturable absorber (SA). By inserting this SA into the YDF laser cavity, stable Q-switching operation at 1.06 μm is achieved. The Q-switched pulses have the shortest pulse duration of 1.95 μs, the maximum pulse energy of 17.9 nJ and a tunable pulse-repetition-rate from 8.3 to 29.1 kHz. Our results indicate that the TI as a SA is also available at 1 μm waveband, revealing its potential as another wavelength-independent SA (like graphene).

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Passive Q-switching or mode-locking by placing a saturable absorber inside the laser cavity is one of the most effective and popular techniques for pulse generation. However, most of the current saturable absorbers cannot work well in the visible spectral region, which seriously impedes the progress of passively Q-switched/mode-locked visible pulsed fibre lasers. Here, we report a kind of visible saturable absorber-two-dimensional transition-metal dichalcogenides (TMDs, e.g. WS2, MoS2, MoSe2), and successfully demonstrate compact red-light Q-switched praseodymium (Pr(3+))-doped all-fibre lasers. The passive Q-switching operation at 635 nm generates stable laser pulses with ∼200 ns pulse duration, 28.7 nJ pulse energy and repetition rate from 232 to 512 kHz. This achievement is attributed to the ultrafast saturable absorption of these layered TMDs in the visible region, as well as the compact and all-fibre laser-cavity design by coating a dielectric mirror on the fibre end facet. This work may open a new route for next-generation high-performance pulsed laser sources in the visible (even ultraviolet) range.

Water electrolysis offers a promising green technology to tackle the global energy and environmental crisis, but its efficiency is greatly limited by the sluggish reaction kinetics of both the cathodic hydrogen evolution reaction (HER) and anodic oxygen evolution reaction (OER). In this work, by growing amorphous multi‐transition‐metal (cobalt and iron) oxide on two‐dimensional (2D) black phosphorus (BP), we develop a bifunctional electrocatalyst (CoFeO@BP), which is able to efficiently catalyze both HER and OER. The overpotentials for the hybrid CoFeO@BP catalyst to reach a current density of 10 mA cm−2 in 1 m KOH are 88 and 266 mV for HER and OER, respectively. Based on a series of ex‐situ and in situ investigations, the excellent catalytic performance of CoFeO@BP is found to result from the adaptive surface structure under reduction and oxidation potentials. CoFeO@BP can be transformed to CoFe phosphide under reduction potential, in situ generating the real active catalyst for HER.

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In this paper, both nonlinear saturable absorption and two-photon absorption (TPA) of few-layer molybdenum diselenide (MoSe2) were observed at 1.56 μm wavelength and further applied to mode-locked ultrafast fiber laser for the first time to our knowledge. Few-layer MoSe2 nanosheets were prepared by liquid-phase exfoliation method and characterized by x ray diffractometer, Raman spectroscopy, and atomic force microscopy. The obtained fewlayer MoSe2 dispersion is further composited with a polymer material for convenient fabrication of MoSe2 thin films. Then, we investigated the nonlinear optical (NLO) absorption property of the few-layer MoSe2 film using a balanced twin-detector measurement technique. Both the saturable absorption and TPA effects of the few-layer MoSe2 film were found by increasing the input optical intensity. The saturable absorption shows a modulation depth of 0.63% and a low nonsaturable loss of ∼3.5%, corresponding to the relative modulation depth of 18%. The TPA effect occurred when the input optical intensity exceeds ∼260 MW∕cm 2. Furthermore, we experimentally exploit the saturable absorption of few-layer MoSe2 film to mode lock an all-fiber erbium-doped fiber laser. Stable soliton mode locking at 1558 nm center wavelength is achieved with pulse duration of 1.45 ps. It was also observed that the TPA process suppresses the mode-locking operation in the case of higher optical intensity. Our results indicate that layered MoSe2, as another two-dimensional nanomaterial, can provide excellent NLO properties (e.g., saturable absorption and TPA) for potential applications in ultrashort pulse generation and optical limiting.