The objective of the present study was to determine the cross-protection of Ingelvac PRRS MLV against challenge with the new lineage 1 PRRSV emerged in China in pigs. Two lineage 1 PRRSV strains (FJZ03 and FJWQ16 originated from recombination event between NADC30 and JXA1-like strain). We found that pigs vaccinated with the vaccine were protected against challenge with the FJZ03 as shown by fewer days of clinical fever, reduced lung pathology scores, lower PRRS virus load in the blood and developed broadly neutralizing antibodies with high titers to FJZ03. In contrast, vaccine provided limited protection against challenge with FJWQ16 with higher fever, lower antibody titers, lower neutralizing antibodies and higher viral loads in blood. These results demonstrate PRRSV-MLV provides incomplete protection against new lineage 1 PRRSVs.
Wensvoort et al., 1992). The disease has caused tremendous economic losses in the global swine industry. PRRS virus (PRRSV), a positive single-stranded RNA virus of the order Nidovirales, family Arteriviridae is the aetiologic agent of this disease (Cavanagh, 1997). The viral RNA genome is approximately 15.4 kb in size and consists of at least ten open reading frames (ORFs) (Johnson et al., 2011). ORF1a and ORF1b comprise almost 80% of the viral genome and encode at least 16 non-structural proteins (Nsps) involved in viral replication (Fang & Snijder, 2010; Fang et al., 2012). ORF2a to 7 encode eight viral structural proteins: GP2a (encoded by ORF2a), E (encoded by ORF2b), GP3 (encoded by ORF3), GP4 (encoded by ORF4), GP5a
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