Background: Osteoclasts, which are multinucleated cells formed by monocyte fusion, play a key role in bone resorption. Hypoxia-inducible factor (HIF)-1α is vital for the development of osteoclasts in hypoxic environments and during bone resorption. However, additional research is required to further study the HIF-1α-dependent regulation of osteoclast differentiation at the genetic level.Methods: In our study, RNA sequencing (RNA-seq) was used to identify the expression profiles of long noncoding RNAs (lncRNAs) and mRNAs in conditional HIF-1α-knockout osteoclasts.Results: A total of 1,320 mRNAs and 95 lncRNAs were differentially expressed. The expression of lncRNAs MSTRG.7566.12 and MSTRG.31769.2 were strongly negatively correlated with that of Mmp9, Ctsk, etc.Conclusion: Our research provides a basis for further understanding the role of mRNAs and lncRNAs in conditional HIF-1α-knockout osteoclasts, and many of these molecules may be potential targets for treating bone diseases related to HIF-1α.
We numerically solve the time-dependent Ginzburg–Landau equations for two-gap superconductors using the finiteelement technique. The real-time simulation shows that at low magnetic field, the vortices in small-size samples tend to form clusters or other disorder structures. When the sample size is large, stripes appear in the pattern. These results are in good agreement with the previous experimental observations of the intriguing anomalous vortex pattern, providing a reliable theoretical basis for the future applications of multi-gap superconductors.
The thermoelectric (TE) properties of the newly proposed Kagome‐like arsenene (Kagome–As) and antimonene (Kagome–Sb) 2D materials are studied by first‐principles method and Boltzmann transport theory. Kagome–As and Kagome–Sb monolayers are found to exhibit large power factor (PF) due to the large Seebeck coefficient and high electrical conductivity. Meanwhile, the Kagome–As and Kagome–Sb have low thermal conductivity of 2.97 and 0.94 W m−1 K−1 at 300 K, respectively. Combined excellent PF and suppressed thermal conductivity, the Kagome–As and Kagome–Sb are expected to have good TE performance with the maximal ZT values reaching up to 0.66 and 2.52 at 300 K, respectively. The Kagome‐like group‐V elemental monolayers are promising TE candidates and shed light on the theoretical design of high‐performance 2D materials, which are demonstrated in the results.
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