Live streaming commerce as a popular marketing method has attracted wide attention, but little is known about why consumers continue to watch live streaming. To fill this research gap, this study draws on social presence theory to examine the impact of sense of community, emotional support, and interactivity on viewers’ social presence, which, in turn, influences their live streaming watching. Furthermore, the moderating role of streamer attractiveness is also investigated. The authors collected survey data from 386 live streaming viewers and used the structural equation model to test the research model. The results reveal that sense of community, interactivity, and emotional support positively affects viewers’ social presence, leading to viewers’ watching live streaming. Furthermore, streamer attractiveness plays a significant moderating role between social presence and live streaming watching. This study provides a unified theoretical framework to explain the intention to watch live streaming based on social presence theory.
In this paper, a novel kind of zwitterion modified graphene oxide (GO) for promoting stability and reducing aggregation of GO as a drug carrier was proposed and demonstrated. Specifically, the GO was functionalized with a kind of zwitterion based silane, 3-(dimethyl(3-(trimethoxysilyl)propyl)-ammonio)propane-1-sulfonate (SBS). After zwitterion modification, the SBS functionalized GO (GO-SB) shows significantly enhanced stability in both serum-free and serum-containing solution, especially after loading doxorubicin hydrochloride (DOX). According to drug release profiles, the drug-loaded GO-SB exhibits thermosensitive and sustained release behavior. Meanwhile, in vitro studies show that the DOX loaded GO-SB could be easily internalized by HepG2 cells and exhibit obvious cytotoxicity on the cells. And, in vivo studies demonstrate that the GO-SB drug carrier is capable of being taken by the larvae of zebrafish and can be eliminated from the body within several days.
We demonstrated an extremely facile way to fabricate inorganic-organic microgels with pH sensitivity and fluorescence. Aqueous dextran microgels are crosslinked by ZnO quantum dots (QDs). The ZnO@Dextran microgels were synthesized by simply mixing amino-modified ZnO (ZnO QDs) with carboxymethyl dextran (CMD) while stirring. The hybrid microgels showed an average diameter of 5 lm and strong fluorescence under ultraviolet (365 nm) irradiation. Up to 79.3 wt % of ZnO QDs were loaded into microgels. The ZnO QDs crosslinkage in the hybrid microgels structure enabled the microgels to degrade under mild acidic environment due to pH sensitivity of ZnO QDs. After loading of doxorubicin (Dox), the microgels were used as drug carriers for pHcontrolled release of Dox. The degradation of the microgels and the release of loaded cargos could be monitored by detecting fluorescence intensity of the microgels. Moreover, owing to the cytotoxicity of ZnO QDs at their destination, drug-loaded ZnO@Dextran microgels can be used for synergistic therapy.
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