This study used the Strengths (S), Weaknesses (W), Opportunities (O) and Threats (T) (SWOT) analysis method, drawing on our experience of the response to the 2003 SARS epidemic, the 2019 China Health Statistics Yearbook data, and changes in China's policy environment for the pneumonia epidemic response relating to the novel coronavirus (COVID-19) infection, to perform a systematic analysis of the COVID-19 epidemic prevention and control strategy S, W, O, and T, with a further analysis of a strategic foundation and to determine a significant and relative strategy. We assessed and formulated strength-opportunity (SO), weakness-opportunity (WO), strength-threat (ST), and weakness-threat (WT) strategies for the prevention and control of the COVID-19 epidemic. We conducted an in-depth analysis and identified the highest-priority policies. These are: reshaping the emergency system (SO1); adding health emergency departments to universities and other institutions (WO2); adjusting the economic structure and strengthening international and domestic linkages (ST2); and strengthening public intervention in responding to public health emergencies (WT1).

The 7(th) edition is considered to be valid for patients with resected ESCC. However, the histologic grade and cancer location were not prognostic factors for ESCC.

Ribosome production in eukaryotes requires the complex and precise coordination of several hundred assembly factors, including many small nucleolar RNAs (snoRNAs). However, at present, the distinct role of key snoRNAs in ribosome biogenesis remains poorly understood in higher plants. Here we report that a previously uncharacterized C (RUGAUGA)/D (CUGA) type snoRNA, HIDDEN TREASURE 2 (HID2), acts as an important regulator of ribosome biogenesis through a snoRNA–rRNA interaction. Nucleolus-localized HID2 is actively expressed in Arabidopsis proliferative tissues, whereas defects in HID2 cause a series of developmental defects reminiscent of ribosomal protein mutants. HID2 associates with the precursor 45S rRNA and promotes the efficiency and accuracy of pre-rRNA processing. Intriguingly, disrupting HID2 in Arabidopsis appears to impair the integrity of 27SB, a key pre-rRNA intermediate that generates 25S and 5.8S rRNA and is known to be vital for the synthesis of the 60S large ribosomal subunit and also produces an imbalanced ribosome profile. Finally, we demonstrate that the antisense-box of HID2 is both functionally essential and highly conserved in eukaryotes. Overall, our study reveals the vital and possibly conserved role of a snoRNA in monitoring the efficiency of pre-rRNA processing during ribosome biogenesis.

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Cloud computing enables an economically promising paradigm of computation outsourcing. However, how to protect customers confidential data processed and generated during the computation is becoming the major security concern. Focusing on engineering computing and optimization tasks, this paper investigates secure outsourcing of widely applicable linear programming (LP) computations. Our mechanism design explicitly decomposes LP computation outsourcing into public LP solvers running on the cloud and private LP parameters owned by the customer. The resulting flexibility allows us to explore appropriate security/efficiency tradeoff via higher-level abstraction of LP computation than the general circuit representation. Specifically, by formulating private LP problem as a set of matrices/vectors, we develop efficient privacy-preserving problem transformation techniques, which allow customers to transform the original LP into some random one while protecting sensitive input/output information. To validate the computation result, we further explore the fundamental duality theorem of LP and derive the necessary and sufficient conditions that correct results must satisfy. Such result verification mechanism is very efficient and incurs close-to-zero additional cost on both cloud server and customers. Extensive security analysis and experiment results show the immediate practicability of our mechanism design. ! 0018-9340 (c)

Objective: Functional constipation (FC) is a common gastrointestinal disorder. Anxiety and/or depressive disorders are common in patients with FC (FCAD). Brain dysfunction may play a role in FC, but the contribution of comorbid anxiety and/or depression in patients with FC is poorly understood. Methods: Sixty-five FC patients and 42 healthy controls (HCs) were recruited, and a hierarchical clustering algorithm was used to classify FC patients into FCAD and patients without anxiety/depressive status (FCNAD) based on neuropsychological assessment. Resting-state functional magnetic resonance imaging measures including fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity were used to investigate brain functional differences. Results: Thirty-seven patients were classified as FCAD, and 28 patients were classified as FCNAD; as compared with HC, both groups showed decreased activity (fALFF) in the perigenual anterior cingulate cortex (pACC), dorsomedial prefrontal cortex (DMPFC), and precuneus; enhanced precentral gyrus-thalamus connectivity and attenuated precuneus-thalamus connectivity in FCAD/FCNAD highlighted the thalamus as a critical connectivity node in the brain network (p FWE < .05). In comparison with FCNAD/HC, the FCAD group also had decreased fALFF in the orbitofrontal cortex (OFC) and thalamus, and increased OFC-hippocampus connectivity. In the FCNAD group, brain activities (pACC/DMPFC) and connection (precuneus-thalamus) had correlations only with symptoms; in the FCAD group, brain activities (OFC, pACC/DMPFC) and connectivities (OFC-hippocampus/precentral gyrus-thalamus) showed correlations with both constipation symptoms and anxiety/depressive status ratings. Mediation analysis indicated that the relationship between abdominal distension and OFC activity was completely mediated by anxiety in FCAD. Conclusions: These findings provide evidence of differences in brain activity and functional connectivity between FCAD and FCNAD, potentially providing important clues for improving treatment strategies.

This phenomenological study explores critical issues related to participation in human resource development (HRD) interventions. Specifically focusing on master of business administration (M.B.A.) training programs in China, we conducted in-depth individual interviews with twelve middle-level managers to understand their perceptions and experience of this academic program during the country's recent transitional period. The findings suggest that HRD participation in a specific transitioning cultural context may present features that have not been explored by previous learning participation studies in either HRD or adult education. In the light of the transitioning nature of the Chinese cultural context, we derived three propositions for future research on HRD learning participation. Practical implications for learning participation are also drawn based on the results of the study.Learning participation is a multidimensional decision process involving program selection, engagement, and completion of a learning activity by a given employee in organizational settings (Wang & Wang, 2004). Employee participation in learning interventions has significant implications for organizational management as well as theory building in human resource development (HRD). To be effective and achieve their intended organizational outcomes, HRD learning interventions depend on employees' full participation and engagement. However, unlike its counterpart in adult education research, employee participation in HRD interventions has received limited attention from researchers except a few empirical studies in management and industry and organization (I/O) psychology literature (Hicks & Klimoski, 1987;Maurer & Tarulli, 1994;Noe & Wilk, 1993). As a result, there is only sparse literature to help us understand why employees participate in HRD interventions and what their experience feels like and means to them.This study explores learning participation from a management development (MD) perspective for two reasons. First, MD is a core component of HRD (Brewster, 2004). In fact, continuing radical environmental and organizational changes have precipitated a search for a more strategic and integrated model of developing individuals who lead and manage organizations (Garavan, Barnicle, & O'Suilleabhain, 1999). Within this changing context, MD is viewed as a major driver and facilitator of change and adaptation (Beddowes, 1994;Storey, 1989aStorey, , 1989b and the key to organizational renewal (McClelland, 1994). Second, while the importance of MD to organizational effectiveness and success is increasingly recognized (Brewster, 2004;Mabey, 2004; Peteraf, 1993;Wright, Dunford, & Snell, 2001;Youndt, Scott, Dean, & Lepak, 1996), considerable debate exists among academics and practitioners on the value and impact of MD interventions, as reported by a number of empirical studies (Luoma, 2005;Meldrum & Atkinson, 1998;Winterton & Winterton, 1997). Problem: The Case of ChinaThis study is situated in the context of the People' s Republic of China. China ...

To summarize the present status of health emergency management assessment in China, a comprehensive search of Chinese databases for research that explicitly mention health emergency assessment indicators and indicator systems was performed. Studies were evaluated using the Ekman quality assessment tool, and data were extracted with an original extraction form. Sixty-one studies were included. There are many types and methods of health emergency management assessment in China, and the dimensions and the indicators involved are complex. Legal, regulatory, and policy bases for such assessment need to be further strengthened. The relevance of the entire assessment process and its practical application should be enhanced. In the occupational practice, appropriate evaluation methods should be selected according to respective evaluation purposes, evaluation objects, and contents. Laws, regulations, and policies in the evaluation of health emergency management should be improved. Finally, further correlational research on health emergency management evaluation system processes should be explored and improved.