Wireless piezoelectric microrobots are biomedical devices with a potential use in high-precision minimally invasive therapies.

wound healing. [3] Cell epigenetics could be induced by EMF exposure that promotes efficient somatic cell reprogramming. [4] EMF has been used to modulate conditions affecting the nervous system the regeneration of the dopaminergic neuron, thereby compensating for altered electric communication between neurons. [5] For EMF therapies, the invasiveness brought by placing wired electrodes with operation is still a big problem. [6] Piezoelectric nanomaterials are very promising tools for wireless, non-invasive, and targeted neural stimulation. They can

A bioinspired photodetector with signal transmissible to neuron cells is fabricated. Photoisomerization of the dye molecules embedded in the ferroelectric polymer membrane achieves electric polarization change under visible light. The photodetector realizes high sensitivity, color recognition, transient response, and 3D visual detection with resolution of 25 000 PPI, and, impressively, directly transduces the signal to neuron cells.

Myeloid-derived suppressor cells (MDSCs) are garnering increasing attention given their role in tumor development. Herein, a nano-enabled strategy is demonstrated for the eradication of tumor-infiltrated MDSCs by reversing hypoxia. Oxygen-independent photodynamic bismuth tungstate nanoparticles (Bi 2 WO 6 NPs) are loaded into reactive oxygen species (ROS) responsive platelet membranes (PMs) to form a hybrid (PM-BiW NPs). P-Selectin on PMs endows PM-BiW NPs with selectivity toward cancer cells. Once in the tumor, laser illumination stimulates the Bi 2 WO 6 NPs photothermally and photodynamically, which produces enormous quantities of hydroxyl radicals. These hydroxyl radicals help rupture the PM and mitigate hypoxia with the assistance of ionizing radiation. This effectively remodels the tumor micro environment toward one disfavoring the recruitment of MDSCs and contributes to better prognosis. To better understand the mechanism, the expression levels of a set of markers are monitored. It is found that the downregulations of hypoxia-inducible factor-1α, ectonucleoside triphosphate diphosphohydrolase 2, and adenosine-5-phosphoricacid are behind the blocked infiltration of MDSCs. This platform strategy offers a promising approach to overcome the immunosuppression caused by MDSCs through a trimodal therapy integrating the power of photothermal and photodynamic therapy in addition to radiation therapy. Scheme 1. Working principle of PM-BiW NPs. In radical-free RT treatment, oxygen is essential for reaction with the broken end of DNA to augment the damage to an extent beyond the cells' repairing power. This leads to a deteriorated hypoxia condition that helps to recruit MDSCs and inhibits the function of CTLs. For PTT/PDT/RT treatment, in the presence of PM-BiW • OH radicals generated upon illumination can cause the destruction of ROS-responsive PM, followed by their release into cytosol where they behave as a sensitizer for irradiation. As the generation of • OH is fueled by H 2 O, there is no longer oxygen consumption. Thus, the tumor microenvironment is remodeled in such a way that the recruitment of MDSCs is disfavored. This also helps the CTLs respond to stress condition to act effectively against tumors.www.afm-journal.de www.advancedsciencenews.com (3 of 18)

Ferroelectric polymers are of interest as most promising electroactive materials. Flexible transducers from ferroelectric polymer thin film with underneath semiconducting polymer active layer for high sensitive and versatile detection of physiological signals are described. When attached directly on the wrist, the flexible transducers can distinguish the transient pulse waves non‐invasively and in situ, due to their fast response (milliseconds) and high sensitivity (down to several Pascal) to instantaneous change of blood pressure. High‐resolution picture of one pulse wave is available to provide two most common parameters for arterial stiffness diagnosis. The transducers are also suitable for dynamic recognizing physiological signals under both physical exercise and medicine treatment, demonstrating their enormous potential for warning the risk of cardiovascular disease, and evaluating the efficacy of heart medicines. The transducers are easy to carry around with an operating voltage of 1 V and the power consumption less than 1 μW. Thus, they are valuable for applications like electronic skin and mobile health monitoring.