Magnetically driven piezoelectric soft microswimmers for neuron-like cell delivery and neuronal differentiation

Chen, Xiang‐Zhong; Liu, Jia-Hao; Dong, Mei; Müller, Lucas O.; Chatzipirpiridis, George; Hu, Chengzhi; Terzopoulou, Anastasia; Torlakcik, Harun; Wang, X.; Mushtaq, Fajer; Puigmartí‐Luis, Josep; Shen, Qun; Nelson, Bradley J.; Pané, Salvador

doi:10.1039/c9mh00279k

Cited by 105 publications

(123 citation statements)

References 39 publications

(41 reference statements)

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“…Magnetoelectric nanoparticles are another great candidate for neural stimulation. It has been already proven that the piezoelectric materials can generate electric signals under the acoustic wave and can induce neural cell differentiation (Chen et al, 2019). As ferromagnetism and ferroelectricity are coupled to each other, applied external magnetic field can induce variation in electric polarization of nanoparticles, causing a change of the electronic structure at the particle surface and therefore facilitating stimulation of the tissue deep inside the brain (Kargol et al, 2012; Guduru et al, 2015).…”

Section: Future Perspectivesmentioning

confidence: 99%

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes

et al. 2019

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The development of implantable neuroelectrodes is advancing rapidly as these tools are becoming increasingly ubiquitous in clinical practice, especially for the treatment of traumatic and neurodegenerative disorders. Electrodes have been exploited in a wide number of neural interface devices, such as deep brain stimulation, which is one of the most successful therapies with proven efficacy in the treatment of diseases like Parkinson or epilepsy. However, one of the main caveats related to the clinical application of electrodes is the nervous tissue response at the injury site, characterized by a cascade of inflammatory events, which culminate in chronic inflammation, and, in turn, result in the failure of the implant over extended periods of time. To overcome current limitations of the most widespread macroelectrode based systems, new design strategies and the development of innovative materials with superior biocompatibility characteristics are currently being investigated. This review describes the current state of the art of in vitro, ex vivo , and in vivo models available for the study of neural tissue response to implantable microelectrodes. We particularly highlight new models with increased complexity that closely mimic in vivo scenarios and that can serve as promising alternatives to animal studies for investigation of microelectrodes in neural tissues. Additionally, we also express our view on the impact of the progress in the field of neural tissue engineering on neural implant research.

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Section: Future Perspectivesmentioning

confidence: 99%

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes

et al. 2019

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“…In situ polymerization on cell surface 11 and enzymatic reaction in the cells 13,66,67 or tissues 68 Neuron regulation 11 and cancer therapy 13,[65][66][67][68] Ultrasound Piezoelectric materials 3D cyclic mechanical stimulation, 76 electrical stimulation, 77,78 ultrasound stimulation for polymer, 79 nanoparticle-laden cells, 80 and microswimmers 81 Stem cell differentiation, 76,77,78 signal transduction, 79,80 and cell delivery and differentation 81 controlled in 2D arrays by an external magnetic field on the surface of substrate materials. These 2D arrays of the MNPs enable reversible cell adhesion on the substrate surface.…”

Section: Organometallic Complexationmentioning

confidence: 99%

“…The micromachines were designed as composites composed of piezoelectric polymer materials in which MNPs were dispersed. 81 Piezoelectric polymer functioned as an ultrasound-responsive electrostimulation platform for cells, whereas the MNPs enabled the magnetic actuation of the micromachines. By applying a rotating magnetic field, the micromachines exhibit the active motion.…”

Section: Piezoelectric Materialsmentioning

confidence: 99%

“…80 The MNP-embedded piezoelectric micromachines were shown to simultaneously enable the magnetic actuation of the micromachines and ultrasound-responsive electrostimulation of the cells loaded on their surface. 81 This approach is promising for targeted cell transportation and differentiation in vivo. The combinational use of ultrasound with piezoelectric materials offers promising potential for the development of noninvasive neuroregenerative devices.…”

Section: Mechanical Electrical and Ultrasound-based Control Of Cellmentioning

confidence: 99%

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Remote active control of nanoengineered materials for dynamic nanobiomedical engineering

Kim

Choi

Shin

et al. 2020

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Cells dynamically interact with native nanostructured extracellular matrix at a molecular level in vivo. Developing remotely and actively controllable nanoengineered biomaterials can manipulate and unravel complex cell-material interactions that dynamically occur in the nanoscale in vivo. In this review, we discuss emerging advances in a myriad of recent nanoengineering technologies to design remotely manipulable materials that enable dynamic nanobiomedical engineering at the molecular level. In particular, we focus on remote active stimuli, such as magnetic fields, light, in situ self-assembly, and ultrasound, to manipulate dynamic cell-material interactions in both in vitro and in vivo settings. Remote active control can be particularly appealing with targeting capability for particular locations at any prescribed time points with a degree of reversibility. The unique remote controllability enables the regulation of cellular signaling, adhesion, differentiation, and polarization; cell, drug, and gene delivery; and in situ self-assembly. These materials allow the remote control in regenerative medicine, immunotherapy, cancer therapy, and biocatalysis as well as mechanistic studies on dynamic nanoscale cell-material interactions. We also highlight current challenges in the remote active control, such as reproducibility, tissue-penetrative capability, noninvasive surgery, spatial localization, and temporal variation. Albeit remotely and actively controllable nanoengineered biomaterials are in the nascent stage of development, they can evolve into multiresponsive, reversible, and cost-effective three-dimensional systems with safe and convenient long-term control at the cell, tissue, and organ level toward clinical patient-tailorable on-demand therapy. K E Y W O R D S dynamic nanobiomedical engineering, magnetic control, nanoengineered biomaterial, photonic control, remote active control, self-assembly-based control This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…[ 3a,c,6 ] However, most of the reported cell‐transporting microrobots are made of hard materials, which fail to provide a supportive and/or stimulating microenvironment for the cells, or to degrade once they have accomplished their delivery tasks. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

3D‐Printed Soft Magnetoelectric Microswimmers for Delivery and Differentiation of Neuron‐Like Cells

Dong

Wang

Chen

et al. 2020

Adv Funct Materials

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190

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Neurodegenerative diseases generally result in irreversible neuronal damage and neuronal death. Cell therapy shows promise as a potential treatment for these diseases. However, the therapeutic targeted delivery of these cells and the in situ provision of a suitable microenvironment for their differentiation into functional neuronal networks remain challenging. A highly integrated multifunctional soft helical microswimmer featuring targeted neuronal cell delivery, on-demand localized wireless neuronal electrostimulation, and post-delivery enzymatic degradation is introduced. The helical soft body of the microswimmer is fabricated by two-photon lithography of the photocurable gelatin-methacryloyl (GelMA)-based hydrogel. The helical body is then impregnated with composite multiferroic nanoparticles displaying magnetoelectric features (MENPs). While the soft GelMA hydrogel chassis supports the cell growth, and is degraded by enzymes secreted by cells, the MENPs allow for the magnetic transportation of the bioactive chassis, and act as magnetically mediated electrostimulators of neuron-like cells. The unique combination of the materials makes these microswimmers highly integrated devices that fulfill several requirements for their future translation to clinical applications, such as cargo delivery, cell stimulation, and biodegradability. The authors envision that these devices will inspire new avenues for targeted cell therapies for traumatic injuries and diseases in the central nervous system.

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Magnetically driven piezoelectric soft microswimmers for neuron-like cell delivery and neuronal differentiation

Abstract: Wireless piezoelectric microrobots are biomedical devices with a potential use in high-precision minimally invasive therapies.

Cited by 105 publications

References 39 publications

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes

Tissue Response to Neural Implants: The Use of Model Systems Toward New Design Solutions of Implantable Microelectrodes

Remote active control of nanoengineered materials for dynamic nanobiomedical engineering

3D‐Printed Soft Magnetoelectric Microswimmers for Delivery and Differentiation of Neuron‐Like Cells

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