Molecular testing for the BRAFV600E mutation in FNA thyroid nodule specimens increases diagnostic value when applied in a BRAFV600E mutation-prevalent population. However, when using this potentially powerful technique, we must consider both its strengths and its weaknesses.

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This study investigates the relationship between selected predictors of achievement in playing unrehearsed music (sight reading) and the changing complexity of sight reading tasks. The question under investigation is, how different variables gain or lose significance as sight reading stimuli become more difficult. Fifty-two piano major graduates and undergraduates took part in an experiment which consisted of five different levels of sight reading complexity. Predictor variables were divided into three categories: (i) general cognitive skills (e.g. working memory capacity); (ii) elementary cognitive skills (e.g. reaction time); and (iii) expertise-related skills (e.g. accumulated sight reading or inner hearing). Regression analyses indicate that when sight reading stimuli is easy, general pianistic expertise is sufficient to be able to excel. However, with increasing task difficulty, psychomotor speed (as indicated by trilling speed), speed of information processing, inner hearing and sight reading expertise become more important. When sight reading complexity reaches its highest level, sight reading expertise still remains important, but psychomotor speed becomes the dominant predictor. Results indicate (i) that psychomotor speed and speed of information processing have a 'bottleneck' function and (ii) that there is a critical time window up to the age of 15 when sight reading expertise has to be acquired. It is concluded that with increasing task demands, sight reading ability is determined by both practice dependent skills and skills which are also assumed to be limited by innate abilities such as psychomotor movement speed. Thus we explain sight reading achievement as the result of specific combinations of different categories of skills which change with the demands of a task.

BackgroundConcern regarding the health-related quality of life (HRQOL) of long-term survivors of thyroid cancer has risen due to the rapid increase in the incidence of thyroid cancer, which generally has an excellent prognosis. The aim of this study was to evaluate the status of HRQOL in disease-free survivors of differentiated thyroid carcinoma (DTC) and to evaluate the important determinants of HRQOL.MethodsThis was a cross-sectional study in which we interviewed consecutive disease-free survivors of DTC. Three different validated questionnaires ("EORTC QLQ-C30" for various functional domains, the "brief fatigue inventory (BFI)" and the "hospital anxiety and depression scale" (HADS)) were used. Data from a large, population based survey of 1,000 people were used as a control.ResultsThe response rate for the questionnaires was 78.9% (316/401). Disease-free survivors of DTC showed a decreased HRQOL in all five functional domains (physical, role, cognitive, emotional, and social) on the EORTC QLQ-C30 compared with controls (P < 0.01). BFI and HADS-anxiety scores also showed greater distress in disease-free survivors of DTC than in controls (P < 0.05). A multiple regression analysis for the determinants of HRQOL showed that the HADS-anxiety, HADS-depression, and BFI scores were the most significant components of decreased HRQOL.ConclusionsAlthough disease-free survivors of DTC are expected to have disease-specific survival comparable to the general population, they experience a significantly decreased HRQOL. Anxiety, depression, and fatigue were the major determinants of the decreased HRQOL. Supportive psychological care should be integrated into the management of long-term survivors of DTC.

We demonstrated that the I/Cr ratio from spot urine could serve as a useful and reliable alternative to 24-h urine collection as it has acceptable diagnostic values for detecting poor LID preparation.

The unrehearsed performance of music, called ‘sight-reading’ (SR), is a basic skill for all musicians. It is of particular interest for musical occupations such as the piano accompanist, the conductor, or the correpetiteur. However, up until now, there is no theory of SR which considers all relevant factors such as practice-related variables (e.g. expertise), speed of information processing (e.g. mental speed), or psychomotor speed (e.g. speed of trills). Despite the merits of expertise theory, there is no comprehensive model that can classify subjects into high- and low-performance groups. In contrast to previous studies, this study uses a data mining approach instead of regression analysis and tries to classify subjects into predetermined achievement classes. It is based on an extensive experiment in which the total SR performance of 52 piano students at a German music department was measured by use of an accompanying task. Additionally, subjects completed a set of psychological tests, such as tests of mental speed, reaction time, working memory, inner hearing, etc., which were found in earlier studies to be useful predictors of SR achievement. For the first time, classification methods (cluster analysis, regression trees, classification trees, linear discriminant analysis) were applied to determine combinations of variables for classification. Results of a linear discriminant analysis revealed a two-class solution with four predictors (cross-validated error: 15%) and a three-class solution with five predictors (cross-validated error: 33%).

Antimicrobial peptides (AMPs) are promising therapeutic agents for treating antibiotic-resistant bacterial infections. Previous studies showed that magainin 2 (isolated from African clawed fogs Xenopus laevis) has antimicrobial activity against gram-positive and gram-negative bacteria. The present study was conducted to investigate the antibacterial activity of magainin 2 against Acinetobacter baumannii. Magainin 2 showed excellent antibacterial activity against A. baumannii strains and high stability at physiological salt concentrations. This peptide was not cytotoxic towards HaCaT cells and showed no hemolytic activity. Biofilm inhibition and elimination were significantly induced in all A. baumannii strains exposed to magainin 2. We confirmed the mechanism of magainin 2 on the bacterial outer and inner membranes. Collectively, these results suggest that magainin 2 is an effective antimicrobial and antibiofilm agent against A. baumannii strains.

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