Usefulness of iodine/creatinine ratio from spot‐urine samples to evaluate the effectiveness of low‐iodine diet preparation for radioiodine therapy

Kim, Hee Kyung; Lee, Soo-Youn; Lee, Ji In; Jang, Hye Won; Kim, Sang-Yong; Chung, Haegeun; Tan, Alice Hyun Kyung; Hur, Kyu Yeon; Kim, Jae Hyun; Chung, Jae Hoon; Kim, Sun Wook

doi:10.1111/j.1365-2265.2009.03774.x

Cited by 42 publications

(52 citation statements)

References 22 publications

(43 reference statements)

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“…The effect of creatinine on the variability of the measurement of UIC is also disputed. For example, Kim et al found that the 24-h urinary iodine excretion correlated more strongly with the iodine:creatinine ratio rather than with the simple UIC [36] . Other authors discourage the use of the iodine:creatinine ratio because of its higher variability [2,35] .…”

Section: Discussionmentioning

confidence: 96%

Potentiometric measurement of urinary iodine concentration in patients with thyroid diseases with and without previous exposure to non-radioactive iodine

Giovacchini¹,

Giovanella²,

Haldemann³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Section: Discussionmentioning

confidence: 96%

Potentiometric measurement of urinary iodine concentration in patients with thyroid diseases with and without previous exposure to non-radioactive iodine

Giovacchini¹,

Giovanella²,

Haldemann³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…Kim et al [23] demonstrated that the I/Cr ratio from a spot-urine sample could serve as a useful and reliable alternative to 24-hour urine collection to evaluate the appropriateness of an LID prior to RAI therapy. They enrolled 193 patients and collected 24-hour urine samples (µg/day) and fasting spot-urine samples (µg/L and µg/gCr).…”

Section: Can the I/cr Ratio From A Spot-urine Sample Replace 24-hour mentioning

confidence: 99%

“…A simple UIC has been proposed as a marker for iodine status in epidemiological studies [24-26]; however, this measurement could underestimate daily iodine excretion in patients with a urinary volume of more than 1 L/day and be affected by dilution status. Kim et al [23] found that a simple UIC had a weaker correlation than the I/Cr ratio; however, the I/Cr ratio has a limitation in that it may overestimate iodine intake in patients with malnutrition or poor muscle mass because of low Cr levels.…”

Section: Can the I/cr Ratio From A Spot-urine Sample Replace 24-hour mentioning

confidence: 99%

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Low Iodine Diet for Preparation for Radioactive Iodine Therapy in Differentiated Thyroid Carcinoma in Korea

Chung

2013

Endocrinol Metab

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Preparation for radioactive iodine (RAI) therapy includes an increased serum thyroid stimulating hormone level and a low iodine diet (LID). Because of extremely high iodine intake, some physicians have advocated a more stringent LID for greater than 2 weeks in Korean patients with thyroid cancer prior to RAI therapy; however, it is very difficult to maintain a stringent LID for a longer period of time. According to recent reports in Korea, a nonstringent, simple LID for only 1 week might be enough prior to RAI therapy, if the patients can be educated intensively by specially trained staff. The measurement of simple urinary iodine concentration (UIC; µg/L) may underestimate daily iodine excretion in patients with a urinary volume of more than 1 L/day and can also be affected by dilution status. Simple UIC had a weaker correlation than the iodine/creatinine (I/Cr) ratio. Therefore, the urinary I/Cr ratio can replace 24-hour urine iodine excretion instead of simple UIC, although it may overestimate iodine intake in patients with malnutrition or poor muscle mass. The measurement of serum iodine level might be useful as an adjunct parameter for assessing LID preparation, but its sensitivity and specificity were relatively low compared to the urinary I/Cr ratio.

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“…Urinary iodine/creatinine ratio (I/Cr) from a random, spot-urine sample could serve as a useful and reliable alternative to 24-hour urine collection [12,13]. …”

Section: Introductionmentioning

confidence: 99%

Excessive Iodine Intake Does Not Increase the Recurrence Rate of Graves' Disease after Withdrawal of the Antithyroid Drug in an Iodine-Replete Area

et al. 2015

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Background and Objectives: The relationship between iodine intake and effects of antithyroid drugs (ATD) for Graves' disease, especially in iodine-deficient areas, has been demonstrated in many studies. However, it was not clear how chronic high iodine intake influenced the effectiveness of ATD in an iodine-replete area. This study aimed to clarify the effect of iodine intake on clinical outcomes of Graves' disease after discontinuation of ATD in Korea, an iodine-replete area. Methods: A total of 142 patients with Graves' disease who visited the outpatient clinic regularly and stopped their ATD between October 2011 and April 2013 were enrolled in our study. Urinary iodine concentration (UIC) was measured just before and after the discontinuation of ATD. Results: Median UIC was not significantly different between the remission and relapse groups, as well as among the four treatment groups (group 1, remission after initial treatment; group 2, remission after repeated treatment; group 3, early relapse within a year; group 4, late relapse after a year). Remission rates did not show a significant difference between the excessive iodine intake (UIC ≥300 μg/l) and average iodine intake groups (UIC <300 μg/l). Conclusions: The present study suggests that excessive iodine intake does not have an effect on the clinical outcomes of Graves' disease in an iodine-replete area, and therefore diet control with iodine restriction might not be necessary in the management of Graves' disease.

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Usefulness of iodine/creatinine ratio from spot‐urine samples to evaluate the effectiveness of low‐iodine diet preparation for radioiodine therapy

Abstract: We demonstrated that the I/Cr ratio from spot urine could serve as a useful and reliable alternative to 24-h urine collection as it has acceptable diagnostic values for detecting poor LID preparation.

Cited by 42 publications

References 22 publications

Potentiometric measurement of urinary iodine concentration in patients with thyroid diseases with and without previous exposure to non-radioactive iodine

Potentiometric measurement of urinary iodine concentration in patients with thyroid diseases with and without previous exposure to non-radioactive iodine

Low Iodine Diet for Preparation for Radioactive Iodine Therapy in Differentiated Thyroid Carcinoma in Korea

Excessive Iodine Intake Does Not Increase the Recurrence Rate of Graves' Disease after Withdrawal of the Antithyroid Drug in an Iodine-Replete Area

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