Background Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM). Recent advances in the knowledge about the cellular, molecular and genetic aspects of fibrosis have opened a new era of research on liver cirrhosis. A transcription factor, Sp1, originally described as a ubiquitous transcription factor, is involved in the basal expression of ECM genes and may be important in the fibrotic processes.

Implant placement in the edentulous anterior mandible is relatively considered a routine and safe procedure. The interforaminal area is the usual area in the mandible for implant placement for the support and retention of a fixed partial denture or removable overdenture. This region is also the usual donor site of bone grafts. However, implant placement, like any other surgical procedure, is not free of risks and complications. The purpose of this review article was to investigate the risk of a life threatening hemorrhage due to arterial injury at implant placement in the anterior mandible.

Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. PRF releases growth factors and matrix glycoproteins. In this study, the Double J technique was used. The Double J technique, which uses centrifuged venous blood that is sampled using 2 different types of DB vacutainers, is a procedure that covers the PRF matrix obtained from 1 of the DB vacutainers on transplanted osseous coagulum, which is obtained using the plasma layer and buffering layer from the second DB vacutainer. Two cases were reported because clinically valid results were obtained. Additional studies are definitely warranted.

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Alveolar bone should be augmented to an adequate height and width for an implant to have satisfactory functional, biological, and aesthetic properties. Large osseous defects often require block grafts harvested from the symphysis or ramus. However, surgical complications and the necessity of donor sites have led to using allogeneic grafting materials. Two patients with severe bone defects on their mandibular posterior and maxillary posterior teeth were selected to be the subjects of this study. These 2 patients needed their implant fixtures removed due to implant failure. They received alveolar ridge augmentation using commercial block allografts, and after an integration period of several months, an implant was placed. The short-term results suggest that block allografts may be suitable bone-replacement materials for augmenting alveolar defects, especially for bone grafts in bone defect areas caused by removing failed implants.