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Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web of Science) on "polyphenols and diabetes" significantly increased since 2010. This review highlights the advances and opportunities of dietary polyphenols as antidiabetic agents.Dietary polyphenols prevent and manage Type 2 diabetes mellitus via the insulindependent approaches, for instance, protection of pancreatic islet -cell, reduction of -cell apoptosis, promotion of -cell proliferation, attenuation of oxidative stress, activation of insulin signaling, and stimulation of pancreas to secrete insulin, as well as the This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. c ○ 2020 The Authors. Food Frontiers published