In this study, we evaluated the effects of high-intensity swimming in an experimental model of acute lung injury (ALI) induced by lipopolysaccharide (LPS) on lung inflammation and antioxidant defenses. Balb/C male mice were submitted to exercise (30 min/day, 5 days/week, for a period of 3 weeks) prior to LPS instillation in the lung. Twenty-four hours after delivery of LPS (10 μg/animal), mice were euthanized and bronchoalveolar fluid (BALF) was obtained for cell counting and analysis of cytokines by ELISA. Lung tissue was used to evaluate antioxidant defenses. LPS instillation resulted in an increase in total and mononuclear cells, IL-1β, TNF-α, and IL-6 in BALF. LPS instillation also altered IL-10 and IL-ra levels in BALF and induced antioxidant defenses (glutathione, superoxide dismutase, catalase, and glutathione peroxidase) in the lung. Protein carbonyl increased in the LPS-treated animals. High-intensity swimming prevented all these changes induced by LPS. Significance: Therefore, this experimental protocol of high-intensity swimming showed a protective effect on ALI, decreasing inflammatory processes and preventing disturbances in antioxidant defenses into the lungs.

Introduction. Moderate aerobic exercise training accelerates the resolution of lung fibrosis in a model of bleomycin-induced pulmonary fibrosis. However, whether it can inhibit the development of lung fibrosis is unknown. Materials and Methods. C57Bl/6 mice were distributed into four groups: Control (Co), Exercise (Exe), Bleomycin (Bleo), and Bleomycin+Exercise (Bleo+Exe). A single bleomycin dose (1.5 UI/kg) was administered orotracheally and treadmill exercise started in the same day, enduring for 4 weeks, 5x/week, 60 minutes/session, at moderate intensity. Lung mechanics, systemic and pulmonary inflammation, and lung remodeling were evaluated. Lung homogenates were used to evaluate the antioxidant status. Results. Total cells, macrophages, lymphocytes, and neutrophils numbers, in agreement with IL-6 levels, were higher in the BAL and serum of Bleo group, compared to other groups. In addition, lung levels of LTB4 in Bleo were higher than other groups, whereas SOD activity and nitric oxide levels in exercised groups (Exe and Exe+Bleo) compared to the Bleo group. Lung GPX activity was lower in Bleo and Exe+Bleo groups compared to others. Exe and Exe+Bleo groups also showed higher IL-10 expression by lung macrophages than other groups, whereas TGF-β expression was higher in Exe, Bleo, and Exe+Bleo groups compared to control. CCR7 expression was induced only in the Exe group. However, exercise did not improve lung remodeling and mechanics, or serum and pulmonary levels of VEGF, IGF-1, and TGF-β. Conclusion. Aerobic exercise training initiated concomitantly with induction of pulmonary fibrosis reduces lung and systemic inflammation but fails to inhibit lung fibrosis and mechanics impairment.

No abstract

No abstract

No abstract

Este trabalho, descritivo com abordagens qualitativa e quantitativa dos dados, investigou as contribuições do slackline, como possibilidade de lazer, para a formação profissional em Educação Física, no contexto de uma universidade pública de Santa Catarina. Dezenove participantes responderam a um questionário contendo perguntas abertas e fechadas, cujas análises foram feitas por meio de análise de conteúdo e estatística descritiva. A maioria dos aspectos avaliados recebeu nível máximo de satisfação. A maioria dos participantes considerou a contribuição do slackline para a futura formação profissional, por representar uma técnica possível de aplicar em diferentes contextos de atuação. Todos os participantes observaram benefícios relacionados à percepção corporal, ao equilíbrio, à força e à propriocepção a partir da vivência do slackline. Os participantes indicaram que poderiam utilizar o slackline para trabalhar a respiração, a tranquilidade e a concentração com adultos ou crianças, no contexto terapêutico ou recreativo; para o fortalecimento da musculatura de crianças de forma lúdica ao ar livre; e também como um recurso para reabilitação de pacientes. Acredita-se que a vivência de slackline contribuiu para que acadêmicos de Educação Física pudessem adquirir conhecimentos sobre esta atividade e para vislumbrá-la como possibilidade de atuação profissional no lazer e em contextos de trabalho específicos.