Chronic kidney disease (CKD) is defined as the atrophy of the kidney or progressive decline of renal function mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD affects more than 10% of the world's population. Moreover, there is no single treatment to improve kidney function in CKD patients. Consequently, this condition is considered a worldwide public health problem. The development of novel CKD therapies is highly needed because current treatment methods are ineffective. Since oxidative stress plays a critical role in CKD, the study of the effect of antioxidants in this pathology is highly important. Dietary antioxidant agents have shown protective effects in CKD. Hence, they may be key for the development of feasible therapies. The aim of this chapter is to provide recent information about the therapeutic role of dietary antioxidants in experimental models of CKD and clinical trials, as well as to describe the mechanisms through which antioxidants exert nephroprotection. The dietary antioxidants revised in this chapter are curcumin, sulforaphane, resveratrol, quercetin, proanthocyanidins, flavan-3-ols, soy protein, red propolis, and Mediterranean diet.