Objective To analyse the expression of BMP7 in osteoblasts and NFATc1 in osteoclasts during the bone healing process in the extraction socket and the possible relationship between the expression of BMP7 and NFATc1. Methodology This study represented a post-test only control group design consisting of four groups, namely; a control group (polyethylene glycol), an ethanol extract of propolis (EEP) group, a bovine bone graft (BBG) group, and a EEP-BBG group. 56 Cavia cobaya were split randomly into four groups. The mandibula left incisors of the subjects were extracted, treated with certain materials according to their group, and sutured. The expression of BMP7 and NFATc1 was observed on day 7 and day 14 by means of immunohistochemical staining. Statistical analysis was performed using a combination of one-way ANOVA, Games-Howell post-hoc, and Pearson tests. Results The propolis-BBG combination group showed the highest BMP7 expression, on both day 7 and day 14. With regard to NFATc1 expression, the combination group experienced the lowest expression on day 7 and day 14. The combination group showed significant differences in all expressions compared to the control group. The BMP7 and NFATc1 expressions showed a strong relationship (r = -0.598, r > 0.5) Conclusion Propolis-BBG combination increases BMP7 expression and reduces NFATc1 expression in the extraction socket. This study confirmed a strong relationship between the expressions of BMP7 and NFATc1.
Objective: This study was intended to analyze the expression of SRT-box transcription factor (SOX)2, SOX9 and woven bone in the preservation of tooth extraction sockets due to induction with propolis extract and bone graft. Materials and methods: 56 Cavia cobaya was divided into four groups according to the socket filling material used: control group, a propolis extract group, a bovine xenograft group, and a propolis extract-bovine xenograft group. An incisor tooth was extracted from each subject and the resulting socket filled with specific materials based on the group of which it was a member. After 3 days and 7 days, the Cavia cobaya were sacrificed in order to obtain their mandibles. Histopathological samples were made by means of hematoxylin-eosin and immunohistochemical staining under a light microscope at 400x magnification. Statistical analysis: The results were analyzed using one-way ANOVA. Results: A combination of propolis extract and bovine xenograft produced the highest expressions of SOX2, SOX9, and woven bone on day 3 and day 7, followed by the propolis group. The combination group experienced a significant difference with the control group on day 3 and day 7 (p<0.001). Even though the combination group presented the highest expressions, the results of a Tukey HSD test indicated no significant difference between the propolis and combination groups on day 3 and day 7. Conclusion: A combination of propolis and bovine xenograft increased the expressions of SOX2, SOX9, and woven bone. Further research is required to validate the bone remodeling acceleration hypothesis with regards to propolis.
Aim: This research was aimed to determine the potential for treating osteogenesis with a combination of zinc oxide and turmeric (ZOT) rhizome liquid extract. Setting and Design: In vivo , post test-control group design. Material and Methods: The mandibular incisors of Wistar rats were extracted and left untreated or received an application of zinc oxideeugenol (ZOE) 10% or ZOT rhizome liquid extract at various concentrations (10%, 20%, and 40%). The mandible was then subjected to immunohistochemical analysis to detect RUNX2 and alkaline phosphatase (ALP) activity. Statistical Analysis Used: One-way ANOVA and Tukey HSD using SPSS software. Results: All groups demonstrated increasing RUNX2 and ALP activity. ZOT 40% showed the highest activity in all groups on day 3 and day 7, although there were no significant differences with ZOE 10%. Conclusion: A combination of ZOT rhizome liquid extract can induce the osteogenic process in postextraction sockets. The results highlight the need for further investigation of the potential osteogenesis of curcumin in humans.
This paper shows the clinical steps for preparing a screw-retained crown for the restoration of a single implant. A 66-year-old female patient came to the clinic wanted to replace partial edentulous after extraction of 24 and 25. Patient wanted to have implant treatment with fixed restoration because he had experienced with the same treatment before in another regions Impression-taking using open-tray technique and delivery of the crown is presented in a step-by-step manner elucidated by detailed photographs. Furthermore, the advantages and disadvantages of screw-retained crowns are discussed in comparison with the cemented restorations.
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