Objective
This study aimed to elicit preferences for attributes of current and novel long-acting antiretroviral therapy for human immunodeficiency virus treatment.
Methods
Primary survey data were collected (July–October 2022) on a sample of 333 people living with human immunodeficiency virus in Germany from a patient recruitment agency. Respondents were invited by e-mail to respond to a web-based questionnaire. After performing a systematic literature review, we conducted qualitative semi-structured interviews to identify and select the key attributes of drug therapy for patients’ preferences for human immunodeficiency virus treatment. Based on this, a discrete choice experiment survey elicited preferences for long-acting antiretroviral therapy characteristics, including the type of medication, frequency of dosing, the location of treatment, the risk of both short-term and long-term side effects, as well as possible interactions with other medications or (party) drugs. A statistical data analysis was performed using multinomial logit models. An additional latent class multinomial logit was performed to evaluate subgroup differences.
Results
Overall, 226 respondents (86% male, mean age 46.1 years) were included in the analysis. The frequency of dosing (36.1%) and the risk of long-term side effects (28.2%) had the greatest influence on preferences. The latent class analysis identified two patient groups. While the first class (
n
= 135; 87% male, mean age 44.4 years) found the frequency of dosing (44.1%) to be most important, the second class (
n
= 91; 85% male, mean age 48.6 years) focused on the risk of long-term side effects (50.3%). The evaluation of structural variables showed that male respondents, those living in small cities or villages, and those with better health status results were significantly more likely to be assigned to the second class (
p
< 0.05 each).
Conclusions
All attributes included in our survey were important to participants when choosing an antiretroviral therapy. We found evidence that the frequency of dosing as well as the risk of long-term side effects have a particular impact on the acceptance of novel therapy regimens and should be considered in order to optimize adherence and satisfaction.
Supplementary Information
The online version contains supplementary material available at 10.1007/s40271-023-00641-y.
Nicole Cage-Florentiny is one of Martinique's most prolific female writers, albeit little known and even less studied. In this interview she explores the role of women in Martinican society, the reason for disturbed male-female relationships, problems with adolescents and issues in education. She explains how her upbringing has influenced her work and how her Judeo-Christian education informs what she writes. Her interest in psychotherapy becomes evident in her continuing search to understand people and their actions, and in her attempt to look into their psyches. However, despite Cage-Florentiny's brutal depiction of Martinican society and her relentless portrayal of taboo subjects such as rape, incest and homosexuality, her works express a desire for a new humanism and a future for healthy male-female relationships. Résumé Nicole Cage-Florentiny est une des plus prolifiques écrivaines de la Martinique, bien que peu connue et même moins étudiée. Dans cette interview, elle explore le rôle des femmes dans la société martiniquaise, la raison pour laquelle les relations homme-femme sont perturbées, les problèmes d'éducation et d'adolescents d'aujourd'hui. Elle explique comment son éducation parentale et judéo-chrétienne a influencé son travail et son écriture. Son intérêt pour la psychothérapie devient évident dans ses efforts pour comprendre les gens et leur comportement, et dans sa tentative de s'immerger dans la psyché des gens. Malgré sa représentation brutale de la société martiniquaise et son portrait acharné des tabous comme le viol, l'inceste et l'homosexualité, ses oeuvres expriment pourtant le désir d'un humanisme nouveau et d'un avenir pour des relations saines entre hommes et femmes.
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