Child English speakers use nonnominative pronouns in subject position but do not tend to use these types of pronouns with finite verbs. Recent findings demonstrate that knowledge of the pronoun paradigm is relevant to pronoun case errors below the 60% correct finiteness marking level but irrelevant above it. We use a receptive test with children who are above the 60% correct finiteness marking level and show that judgments of nominative case and verb finiteness correlate (r = .549, p < .001, n = 49), consistent with the predictions of case theory. Children at this level of finiteness marking show no asymmetry in feminine versus masculine nonnominative errors, but they do allow third singular -s with nonnominatives, which is problematic for both agreement tense omission model and constructivist priming accounts.

The Explainer Video Project was developed to familiarize management students with evaluating explainer videos for credibility and quality. In addition, it provides students with unique options for creating video content. Today’s workplace needs college graduates with entrepreneurial skills applicable to the gig economy enabled by online platforms. The demand for the perpetual creation of new video content generates a need for creators to develop explainer videos. Accordingly, consumers of such content require the necessary skills to evaluate them for credibility and quality. Through the phases of this project, students learn to evaluate explainer videos for quality and credibility and create credible, high-quality explainer videos using a visual communication platform.

Title Linear Mixed-Effects Models using 'Eigen' and S4Contact LME4 Authors Description Fit linear and generalized linear mixed-effects models.The models and their components are represented using S4 classes and methods. The core computational algorithms are implemented using the 'Eigen' C++ library for numerical linear algebra and 'RcppEigen'``glue''.Depends R (>= 3.2.0), Matrix (>= 1.2-1), methods, statsLinkingTo Rcpp (>= 0.10.5), RcppEigen

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Marburg virus (MARV) causes a hemorrhagic fever disease in human and non-human primates with high levels of morbidity and mortality. Concerns about weaponization of aerosolized MARV have spurred the development of non-human primate (NHP) models of aerosol exposure. To address the potential threat of aerosol exposure, a monoclonal antibody that binds MARV glycoprotein was tested for its efficacy as a prophylactic. It was expressed with afucosylated N-glycans and two different sets of Fc amino acid mutations to increase serum half-life: MR186YTE and MR186LS. Each variant was tested in guinea pigs for preventing disease from an aerosolized MARV exposure. While both candidates provided significant protection (P&lt;0.005), the observed efficacy conferred by MR186YTE was slightly superior and this version was selected for further testing in NHPs. MR186YTE was administered intramuscularly to NHPs at 15 or 5 mg/kg one month prior to MARV aerosol challenge. Seventy-five percent (3/4) of the 15 mg/kg dose group and fifty percent (2/4) of the 5 mg/kg dose group survived this lethal challenge. Serum analyses of showed that the NHP dosed with 15 mg/kg that succumbed to infection developed an anti-drug antibody response and therefore had no detectable MR186YTE at the time of challenge. Histopathological analyses found that NHPs that succumbed to disease had lesions consistent with previous reports of MARV disease and inflammatory lesions were noted in all lung lobes. In contrast, NHPs that survived aerosolized MARV exposure had background or non-active infiltrates. No evidence of MARV by immunohistochemistry was noted in the survivors. These results suggest that intramuscular dosing of mAbs may be a clinically useful prophylaxis for MARV aerosol exposure.