2023
DOI: 10.1093/infdis/jiad278
|View full text |Cite
|
Sign up to set email alerts
|

Long-term Prophylaxis Against Aerosolized Marburg Virus in Nonhuman Primates With an Afucosylated Monoclonal Antibody

Abstract: Marburg virus (MARV) causes a hemorrhagic fever disease in human and non-human primates with high levels of morbidity and mortality. Concerns about weaponization of aerosolized MARV have spurred the development of non-human primate (NHP) models of aerosol exposure. To address the potential threat of aerosol exposure, a monoclonal antibody that binds MARV glycoprotein was tested for its efficacy as a prophylactic. It was expressed with afucosylated N-glycans and two different sets of Fc amino acid mutations to … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 38 publications
0
0
0
Order By: Relevance