Darier's disease is a rare autosomal dominant genodermatosis. It has an estimated
prevalence of 1 in 55,000 to 100,000 individuals, regardless of gender. It is
characterized by multiple keratotic papules on the seborrheic areas of the trunk,
scalp, forehead and flexures, and the clinical picture is worsened by heat, sun
exposure, perspiration and mechanical trauma. Histopathology observed loss of
epithelial adhesion and abnormal keratinization. About 10% of cases present in the
localized form of the disease. We report a case of segmental Darier's Disease Type I
and discuss the main characteristics of this condition.
Kaposi's sarcoma (KS) is a multicentric vascular neoplasm, with cutaneous and
extracutaneous involvement. Different clinical and epidemiological variants
have been identified. The classic form is manifested mainly in elderly men
with indolent and long-term evolution, with lesions localized primarily in
the lower extremities. We present two cases of classic Kaposi's sarcoma
(CKS) in two female patients with extensive, exuberant skin involvement and
rapid evolution, with good response to radiotherapy.
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