Systemic administration of the 5‐HT2 agonist 1‐(2,5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane (DOI) (50 and 100 μg kg−1, i.v.) inhibited dorsal raphe neuronal firing. DOI (100 μg kg−1, i.v.) also produced a decrease in extracellular 5‐hydroxytryptamine (5‐HT) and 5‐hydroxyindoleacetic acid (5‐HIAA) in the frontal cortex measured by microdialysis. However, local administration of DOI into the frontal cortex produced no change in extracellular 5‐HT and 5‐HIAA at any dose given (1, 10 and 100 ng). The results demonstrate that DOI is a potent inhibitor of 5‐HT neuronal firing and terminal release and that the effects on release are not mediated by an action within the terminal region. The site of action and the receptor involved in the inhibition remains to be determined.
Sir: Cases of inability to close the eyes voluntarily (apraxia of eye closure') and cases of inability to maintain the eyes closed (eyelid motor impersistence2 3) are known. We report a patient in whom the acquired inability to close the eyes affected alternatively either one or the other eye.A
Intravascular leiomyomatosis (IVL) is a rare benign smooth muscle neoplasm growing within the pelvic venous system, often with caval and intracardiac extension. It frequently coexists with uterine leiomyomas or occurs in women with a history of myomectomy or hysterectomy. IVL is often asymptomatic until intracardiac extension occurs, and carries a risk of sudden death, necessitating timely diagnosis and management. We present a case of IVL diagnosed on hysterectomy specimen with extension to the inferior vena cava found on follow-up imaging. The patient underwent complete resection with multidisciplinary involvement of Gynaecological Oncology and Vascular Surgery and remains disease free following 12 months of follow-up.
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