Scolecite is one kind of natural zeolite. A three component Biginelli reaction using scolecite as a novel heterogeneous acid catalyst is demonstrated. The short reaction time, clean reaction conditions, consistent yields and minimum environmental effects are important features of the reaction.
A clean and simple synthesis of 6-amino-4-aryl-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles was accomplished in good to excellent yields via the one-pot three component condensation of 3-methyl-1-phenyl-2-pyrazolin-5-one, an aromatic aldehyde, and malononitrile catalysed by sulfamic acid in ethanol.
A highly efficient, mild, and simple protocol is presented for the oxidative aromatization of Hantzsch 1, 4-dihydropyridines using the combination of Dess-Martin periodinane with molecular iodine or KBr. The in situ generated acetyl hypoiodite or bromite formed due to the reaction between Dess-Martin periodinane and molecular iodine or KBr respectively is supposed to be the responsible species for bringing about the oxidative aromatization of 1, 4-dihydropyridines.
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