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2. The sentence "Despite their sAppendix uffering, patients rarely seek care due to shame and guilt..." was modified. Please check if the intended meaning is retained.No, this is "Despite their suffering", not "appendix suffering" 3. Please check if the insertion of a closing parenthesis in the sentence "However, it has to be distinguished from paraphilias, which are defined as sexual disorders that are characterized by..." is apppropriate."recurrent, intense sexually arousing fantasies, sexual urges, or behaviors involving sexual activity with ( 1) non-human objects, (2) the suffering or humiliation of oneself or one's partner, or (3) a prepubescent child or children or other nonconsenting persons" [34, 35•]. References [83-85] were provided in the reference list; however, this was not mentioned or cited in the manuscript. As a rule, all references given in the list of references should be cited in the main body. Please provide its citation in the body text.The references 83 to 85 are for the sentence at the end of "other treatments" "In this latter case, a switch to another compound is required. In cases of anxiety, behavioral therapy is recommended as benzodiazepines might be associated with a higher risk of dependence in these patients [83-85]" (and no [78-80] as it is writted) 5. Please provide complete bibliographic details of this references 3, 48, and 49.

Chemsex is an escalating public health issue among men who have sex with men, with potentially severe somatic and psychiatric consequences. Given the limited knowledge and lack of treatment recommendations available in this area, we proposed the use of noninvasive brain stimulation in order to reduce problematic chemsex behavior. This is the first openlabel case report of a positive effect of transcranial direct current stimulation (tDCS) in a patient who was complaining of severe chemsex addiction. Total disappearance of chemsex behavior occurred after 5 days of daily sessions of right prefrontal cortex stimulation and did not return after 8 months of follow-up. The strengthening of dorsolateral prefrontal cortex activity may have modulated limbic pathways and reduced incentive salience and craving of both sexual addiction and concomitant illicit drug use.

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