SUMNARYIn an efficient three-step synthesis L3H] glycerol was converted into d-tosyl-[3H]glycerol (yield: 77%), from which [34 iohexol was prepared in an overall radiochemical yield of 25% and a specific activity of 400 pCi/mmol. Performing the synthesis on a microscale, the overall yield decreased to only 4%, but a 99% pure [3H] iohexol with a specific activity of 1 Ci/mmol was obtained.
1996 stereochemistry stereochemistry (general, optical resolution) O 0030 11 -056 Catalytic Asymmetric Hydroboration with Heterotopic P-N Ligands: Trends in Enantioselectivity with Increased Steric Demand. -Rh-catalyzed hydroboration of alkenes is found to yield (R)-or (S)-products depending on the used ligands forming catalysts of disparate steric environments. -(VALK, J. M.; WHITLOCK, G. A.; LAYZELL, T. P.; BROWN, J. M.; Tetrahedron: Asymmetry 6 (1995) 10, 2593-2596; Dyson Perrins Lab., Oxford OX1 3QY, UK; EN)
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