Six lactating women undergoing contrast media examination had milk and blood taken to determine the rate and extent of excretion of iohexol (Omnipaque) (four mothers) and metrizoate (Isopaque) (two mothers). Blood samples were taken up to 45 minutes and milk samples up to 48 hours after the contrast medium injection. The excretion was low, reaching a maximum at 3 to 6 hours and showing a slow decay curve (tt = 15 to 108 hours). One mother, who was weaning her baby, showed a different excretion pattern. The amount excreted during 24 hours was about 0.5 per cent of the weight adjusted maternal dose for both iohexol and metrizoate. It is not likely, that such a low dose of poorly absorbed drug would cause any adverse effects in the infant, unless it is hypersensitive to the drug already. The authors consider breast feeding to be acceptable for mothers receiving iohexol or metrizoate.
We have found that iopamidol 370 mg I/ml solutions may be greatly supersaturated and iopamidol 300 mg I/ml solutions slightly supersaturated at 4 degrees C and at 25 degrees C. The solubility and degree of supersaturation probably depend on the isomeric purity of the preparation. Some possible implications are discussed.
SUMNARYIn an efficient three-step synthesis L3H] glycerol was converted into d-tosyl-[3H]glycerol (yield: 77%), from which [34 iohexol was prepared in an overall radiochemical yield of 25% and a specific activity of 400 pCi/mmol. Performing the synthesis on a microscale, the overall yield decreased to only 4%, but a 99% pure [3H] iohexol with a specific activity of 1 Ci/mmol was obtained.
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