In this early development study with a limited number of patients, postoperative MAGE-A3 immunization proved to be feasible with minimal toxicity. These results are being investigated further in a large phase III study.

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Summary Introduction. Research in NSCLC biomarker field and application of new methods is essential as it is promising strategy to reduce cancer mortality. Aim of the study. The aim of the study was to develop new approach for lung cancer biomarker research and introduce novel method into surgical practice, verifying method’s safety and evaluate intraoperative and postoperative complications. Materials and methods. 50 patients with early stage NSCLC undergoing lobectomy were randomized into two groups - experimental (n = 25) and control group (n = 25). In experimental group at the time of thoracotomy and resection of the lung, paired blood samples were obtained from the lobar pulmonary vein draining lung segment containing tumor and from the peripheral vein which represents the systemic circulation. Safety of the procedure and its influence on surgery was evaluated. Results. New approach for lung cancer biomarker research was developed. Injuries of major anatomical structures as pulmonary blood vessels, bronchi, trachea and pericardium due to blood sample collection were not observed. There was no difference in hospital stay and chest tube drainage duration. There were no perioperative deaths in both groups. Morbidity rate in experimental group was similar to control group. Conclusions. Application of new method for developing multimodal lung cancer model is safe and does not increase the risk of intraoperative and postoperative complications.

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