The aim of the present study was to investigate the potential of a phospholipid-based microemulsion formulation for parenteral delivery of anticancer drug, etoposide. The microemulsion area was identified by constructing pseudoternary phase diagrams. The prepared microemulsions were subjected to different thermodynamic stability tests. The microemulsion formulations that passed thermodynamic stability tests were characterized for optical birefringence, droplet size, viscosity measurement, and pH measurements. To assess the safety of the formulations for parenteral delivery, the formulation was subjected to compatibility studies with various intravenous infusions and in vitro erythrocyte toxicity study. The developed formulation was found to be robust and safe for parenteral delivery.
Wound healing is a biological process related to growth and tissue regeneration. It includes five stages called overlapping stages with complex biochemical and cellular processes. Topical polymeric films have been used widely for tissue repair of wounds. The primary objective of the research study was to prepare Ofloxacin topical polymeric films with antimicrobial as well as wound healing properties. Ofloxacin is a fluoroquinolone antimicrobial agent which has broad range of activity against gram positive as well as gram negative microorganisms. Ofloxacin films prepared using chitosan, PVA and carbopol showed effective wound healing activity for prolonged time. These films were characterized using various parameters such as thickness, swelling index, in vitro drug release, in vitro diffusion study, etc. The antimicrobial efficiency of the films was evaluated against S. aureus and E. coli. The wound healing activity of the films was determined by testing on female Sprague Dawley rats. The results revealed that Ofloxacin polymeric films can serve as a superior potential topical drug delivery system for wound healing.
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