Studies on Sustained Release Ofloxacin Polymeric Topical Films for Wound Healing

Abstract

Wound healing is a biological process related to growth and tissue regeneration. It includes five stages called overlapping stages with complex biochemical and cellular processes. Topical polymeric films have been used widely for tissue repair of wounds. The primary objective of the research study was to prepare Ofloxacin topical polymeric films with antimicrobial as well as wound healing properties. Ofloxacin is a fluoroquinolone antimicrobial agent which has broad range of activity against gram positive as well as gram negative microorganisms. Ofloxacin films prepared using chitosan, PVA and carbopol showed effective wound healing activity for prolonged time. These films were characterized using various parameters such as thickness, swelling index, in vitro drug release, in vitro diffusion study, etc. The antimicrobial efficiency of the films was evaluated against S. aureus and E. coli. The wound healing activity of the films was determined by testing on female Sprague Dawley rats. The results revealed that Ofloxacin polymeric films can serve as a superior potential topical drug delivery system for wound healing.