The 3D structure of enzyme α-Glucosidase from saccharomyces cerevisiae (Baker's yeast) was developed with the help of homology modeling technique by using target enzyme crystal structure of α-D-glucose bound isomaltase (PDB ID: 3A4A). Modeling was performed through software SWISS-MODEL WORKSPACE; template searching was carried out with BLAST, and HHblits similarity search programs against SWISS-MODEL Template Library (SMTL).The software efficiently searched and we preferentially selected 99.8% the most identical template (3axh.1.A), for modeling. ProMod3 program was used for models built up which wereestablished on the multiple alignment of target-template.The model and templet having conserved coordinates were copied exactly. The fragment library was applied for residual remodeled amino acid`s deletionsand insertions and side chains rebuilding. The global and perresidue model quality was estimated by using the QMEAN scoring function, and it was calculated as (0.91), while accuracy of the developed tertiary structure of model was estimated by GMQE (Global model quality estimation) value which was calculated as (0.99), this indicated the higher reliability of model [34] [Figs 1a-1c].Fig 1aShowing the alignment of the target protein (3A4A) with template protein (3axh.1A
The attributes of the built environment may influence walking in neighbourhood. The objective of this study is to find the association between objectively assessed and perceived built environment attributes. To achieve the objective of the study three neighbourhood of Putrajaya, Malaysia Precinct 8, 9 and 18 were selected. This study used NEWS (Neighbourhood Environment Walkability Scale) abbreviated version for the comparison of the residents' perceptions regarding attributes of three neighbourhoods of Putrajaya in Malaysia that differ on objective measures derived from a GIS (Geographical Information System) data basis and Putrajaya master plan. High-walkable neighbourhood residents reported built environment attributes ratings persistently higher as compared to the residents of the moderate and lowwalkable neighbourhood. Results from the high walkable neighborhood shows that on a 5-point Likert scale most residents perceived high ratings of within the range of "3" except for residential density as there is a different scoring procedure for it. There are lowest ratings perceived within the range of "1" for the attribute crime and according to the scoring procedure for crime lowest score reflects the highest level of walking.There is no significant difference found in the ratings for traffic hazards. Subjective measures of built environment attributes had moderate to high alpha () value. Hence theneighbourhood environment walkability scale can be used for subjective assessment in the tropical context.
Martin Sauvage's book La brique et sa mise en oeuvre en Mésopotamie des origines à l'époque achéménide (1998) provided a comprehensive survey of brick in Ancient Mesopotamia. It measured the size of bricks and showed how they changed in format, looked at mortar types and bonding patterns at different sites and traced the use of fired bricks and sun-dried bricks. The Indus Civilisation flourished about the same time but no similar study has ever been carried out on its brickwork. This research aims to provide just such a study. The world today is facing depleting energy resources. For a country like Pakistan the case is even worse, where the gap between generation and consumption is constantly rising. Therefore, it is needed to efficiently utilize the scarce energy resources. Thus, the architects should pay attention to design and build such constructions that consume comparatively lesser amount of energy. The much acclaimed solution is the constructions of eco buildings. This research dresses the said issue.
'World Heritage Sites' are places or buildings of outstanding universal value recognized as constituting a world heritage 'for whose protection it is the duty of the international community as a whole to co-operate'. The concept of World Heritage is at the core of the World Heritage Convention, adopted by Heritage List as a means of identifying, protecting, conserving and presenting those parts of the world's natural and cultural heritage that are of sufficient 'outstanding universal value' to be the responsibility of the international community as a whole. By joining the Convention, nation states are pledged to safeguard the WH S by protecting their national heritage. UNESCO in 1972, to which 160 nations have now been adhered. The Convention came into force in 1975 and established a Site in their territory as part of a universally agreed policy for World. Moenjodaro site covering an area of 555 Acres out of which only 10 % of it has been excavated by exposing 50 Kilometer standing walls. The wall of the main street of DK G Area, Mohen jo Daro partially deformed, due to the torque effects this is studied here on a lateral cross wall in the chief house. Furthermore, the resulting behaviour of the bucking wall demonstrates the significant loadbearing capacity of the structure under service conditions and its high sensitivity to imposed changes of the geometry. Although the tensile stresses exceeded the flexural strength at the vertices and the length of the wall, hence both the geometry and condition of this area are critical for the safety of the wall. The results of this study can improve the assessment and thus help in the preservation of many important structures of the metropolitan city. Here the hydrous characteristic of the brick is studied as a general phenomenon, it is observed that the remains of the sites located in Sindh suffered a lot mostly due to age, human neglect variations of atmospheric condition, severe temperature and natural disasters. The main causes of decay are summarised as: Salt Action and moisture in filtration from ground and atmosphere direct rains Has also resulted in structural distress including extreme thermal stress, poor site drainage, material decay and visitors behaviour. Hence the brick material is "tired" to performance and its durability decreases under different influences for varying reasons, the causes of decay are material properties or structure properties or by environmental influences thus repair 1 is required. The aim of this paper is to study the main deformation affecting Moenjodaro structures, an archaeological site that prospered from 2350 to 1800 BC, thermal stress causing walls to lean and decay structurally. * Corresponding author. This is useful to know for communication with the appropriate person in cases with more than one author. 1 Repair is a replacing or correction of technical and performance properties of a material (element, structure, and building) to certain serviceability and durability.
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