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We hypothesized that combination of cisplatin and LBH589 can override cisplatin-associated resistance in ovarian cancer cells. These results provide initial evidence for testing this combination in clinical use.

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Consider a composite sandwich plate with balanced or unbalanced anisotropic composite laminated faces and an ideally orthotropic core. A closed-form solution of the buckling load is derived for the composite sandwich plates consisting of cross-ply symmetric laminate faces with all edges simply supported. In addition, a general scheme is developed for the composite sandwich plates with arbitrary sandwich layups, boundary, and loading conditions. By combining the present buckling analysis with PowelPs conjugate direction method, an optimal algorithm is established to find the optimal sandwich layup in resisting biaxial compression, as well as in-plane shear loads.

Objectives: We aimed to utilize a simple molecular assay to simultaneously detect both group B Streptococcus (GBS) and virulent ST-17 rectovaginal colonization. We also attempted to estimate the prevalence of maternal GBS and ST-17 carriers and to evaluate their seasonal association. Subjects and Methods: We used an optimized multiplex PCR method employing scp-B and ST-17 primers to analyze DNA extracted from rectovaginal swabs of 3,064 cases collected over 3 years. The incidence trends, seasonal variations, and temperature preference were analyzed. Results: The overall prevalence of maternal colonization for GBS and ST-17 clone were 13.25 and 2.48%, respectively. The ST-17 to GBS ratio was 18.72%. The occurrence of ST-17 colonization was significantly associated with seasonal variations with a preference for lower temperatures. Conclusions: We developed a novel multiplex PCR method suitable for the simultaneous detection of GBS and ST-17 clone. The phenomenon of lower temperature preference for ST-17 clone necessitates further investigation. The epidemiological data for GBS and ST-17 incidence are especially important to establish a public policy for universal GBS screening in the future.

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