Platelet-associated IgG (PAIgG) and IgM (PAIgM) levels were quantitated in patients with thrombocytopenias of various etiologies. 32 of 34 patients with immune thrombocytopenia had elevated PAIgG, 8 of the 34 patients had elevated PAIgM levels. Only 1 patient suffering from immune thrombocytopenia had elevated PAIgM with normal PAIgG levels. Elevated PAIgM was most often associated with elevated PAIgG except for the following: 2 patients with lymphoproliferative disorders, 1 patient with heparin-induced thrombocytopenia, 1 patient with pernicious anemia, and 2 patients with Waldenström's macroglobulinemia. PAIgM determinations may prove to be a useful adjunct for evaluating patients with thrombocytopenia, particularly those in whom the PAIgG is not elevated.
Platelet-associated IgG (PAIgG) and IgM (PAIgM) levels were quantitated in patients with thrombocytopenias of various etiologies. 32 of 34 patients with immune thrombocytopenia had elevated PAIgG, 8 of the 34 patients had elevated PAIgM levels. Only 1 patient suffering from immune thrombocytopenia had elevated PAIgM with normal PAIgG levels. Elevated PAIgM was most often associated with elevated PAIgG except for the following: 2 patients with lymphoproliférative disorders, 1 patient with heparin-induced thrombocytopenia, 1 patient with pernicious anemia, and 2 patients with Waldenström’s macroglobulinemia. PAIgM determinations may prove to be a useful adjunct for evaluating patients with thrombocytopenia, particularly those in whom the PAIgG is not elevated.
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