The phytochemical and antibacterial studies of the leaf extracts of Flabelleria paniculata cav, have been investigated. Antibacterial activity was investigated using Staphylococcus. aureus, Pseudomonas aerugniosa, Eustaricia coli and Klabellia pneumoniae. The petroleum ether extract was completely inactive. At the concentration of 50mg/ml aqueous extract produced zone of inhibition of 3mm (S. aureus,) and 2mm (Ps. aerugniosa) but was inactive against E. coli and K. pneumoniae. At 10mg/ml chloroform extract produced zone of inhibition of 3mm (S. aureus), 2mm (Ps. aerugniosa), 2mm (F. coil) and 3mm (K. pneumoniae). Chloroform extract showed MIC values of 1 .75 mg/ml and 2mg/ml for Ps. aerugniosa and S. aureus respectively. Saponins, cardenolides, alkaloid and tannins were detected in the leaf. This study justifies the local uses of the plant for the treatment of skin diseases and wounds.

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