Cell lines derived from Hodgkin's disease may provide a clue to the nature of Sternberg‐Reed cells. In the current study, the establishment of an Epstein‐Barr‐virus‐negative lymphoblastoid cell line, derived from the pleural fluid of a patient with the nodular sclerosis type of Hodgkin's diseae, is described. The morphologic and immunologic cell marker findings indicate that this cell line is derived from Sternberg‐Reed cells. The immunologic findings and a chromosomal analysis are in agreement with a B‐lymphocyte origin of these cultured cells. Extrapolation of the results to Hodgkin's disease in vivo would indicate that Hodgkin's disease, like most non‐Hodgkin's lymphomas, is the result of B‐cell proliferation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.