The establishment of 14/300 as a WHO Reference Reagent for high titre anti-A and anti-B in serum, with nominal anti-A and anti-B titres of 128 for DRT, and nominal anti-A and anti-B titres of 256 for IAT, will facilitate global standardization of haemagglutination titrations for anti-A and anti-B in patient samples and blood components.
A family with seven Vel negative (VeVe) members in three generations was found because the propositus had a hemolytic transfusion reaction. She had had four full‐term pregnancies and two miscarriages and one previously uneventful transfusion. The anti‐Vel antibody in her serum gave both hemolysis and agglutination. Study of the blood groups of the family shows that Vea is not in the MNS system. Six of the VeVe individuals were tested with anti‐Fya and all were found to be Fy(a+). Some Ve(a+) bloods were noted to react more strongly with anti‐Vea than others. The explanation of van Loghem and van der Hart that the differences in the intensity of Ve(a+) reactions is due to subgroups, the stronger termed Ve(a1) and the weaker Ve(a2), is accepted by the authors.
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