A juvenile orangutan (Pongo pygmaeus pygmaeus) died after 8 days of diarrhea and vomiting. Necropsy showed petechial hemorrhages in the skin, the myocardium, and the peritoneal membranes. The lungs were hyperemic and edematous, and the liver and spleen were enlarged. Histologic changes consisted of interstitial pneumonia, hepatitis, and splenic hyperplasia. Numerous eosinophilic intranuclear inclusion bodies were visible in pulmonary epithelial cells, hepatocytes, and splenic endothelial cells. Electron microscopic examination revealed herpesvirus in hepatocyte nuclei. Polymerase chain reaction of liver tissue demonstrated the presence of a herpes simplex virus-1.
The successful application of fibroblast and leucocyte interferon in the treatment of juvenile laryngeal papillomatosis in two patients with papillomas extending down into the lower airways is reported. The papillomas recurred during interruption of interferon ad ministration. This indicates that the regression of papillomas is a genuine effect of interferon and not merely a reflection of the capricious natural course of the disease.
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