Treatment of Juvenile Laryngeal Papillomatosis with Two Types of Interferon

Abstract

The successful application of fibroblast and leucocyte interferon in the treatment of juvenile laryngeal papillomatosis in two patients with papillomas extending down into the lower airways is reported. The papillomas recurred during interruption of interferon ad ministration. This indicates that the regression of papillomas is a genuine effect of interferon and not merely a reflection of the capricious natural course of the disease.

Interferons and Bronchogenic Carcinoma in Juvenile Laryngeal Papillomatosis

“…13 During further treatment with interferon-a squamous cell carcinoma of the bronchus was diagnosed in the patient included as case 1 in previous reports. 3,4 Squamous cell carcinomas of the bronchus are rare in the first three decades of life, and in 1981, another case was reported.5 However, several patients in this age group in whom a bronchogenic carcinoma developed during the evolution of juvenile laryn¬ geal papillomatosis have not been included in this series.6"9…”