The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva). The initial configuration and expected performance of the detector and associated systems, as established by test beam measurements and simulation studies, is described.

Purpose: In this work, the design, operation, initial experimental evaluation, and characterization of a small-scale graphite calorimeter probe -herein referred to as the Aerrow -developed for routine use in the clinical environment, are described. Similar in size and shape to a Farmer type cylindrical ionization chamber, the Aerrow represents the first translation of calorimetry intended for direct use by clinical physicists in the radiotherapy clinic. Methods: Based on a numerically optimized design obtained in previous work, a functioning Aerrow prototype capable of two independent modes of operation (quasi-adiabatic and isothermal) was constructed in-house. Reference dose measurements were performed using both Aerrow operation modes in a 6 MV photon beam and were directly compared to results obtained with a calibrated reference-class ionization chamber. The Aerrow was then used to quantify the absolute output of five clinical linac-based photon beams (6 MV, 6 MV FFF, 10 MV, 10 MV FFF, and 15 MV; 63.2% < %dd(10)9 < 76.3%). Linearity, dose rate, and orientation dependences were also investigated. Results: Compared to an ion chamber-derived dose to water of 76.3 AE 0.7 cGy, the average doses measured using the Aerrow were 75.6 AE 0.7 and 74.7 AE 0.7 cGy/MU for the quasi-adiabatic and isothermal modes, respectively. All photon beam output measurements using the Aerrow in waterequivalent phantom agreed with chamber-based clinical reference dosimetry data within combined standard uncertainties. The linearity of the Aerrow's response was characterized by an adjusted R 2 value of 0.9998 in the dose range of 80 cGy to 470 cGy. For the dose-rate dependence, no statistically significant effects were observed in the range of 0.5 Gy/min to 5.4 Gy/min. A relative photon beam quality dependence of 1.7% was calculated in the range of 60 Co to 24 MV (58.4% < %dd(10)9 < 86.8%) using Monte Carlo. Finally, the angular dependence (gantry stationary and detector rotated) of the Aerrow's response was found to be insignificant to within AE0.5%. Conclusions: This work demonstrates the feasibility of using an ion chamber-sized calorimeter as a practical means of measuring absolute dose to water in the radiotherapy clinic. The potential introduction of calorimetry as a mainstream device into the clinical setting is powerful, as this fundamental technique has formed the basis of absorbed dose standards in many countries for decades and could one day form the basis of a new local absorbed dose standard for clinics.

This article reviews the development and summarizes the state-of-the-art in absorbed dose calorimetry for all the common clinical beam modalities covered in reference dosimetry codes of practice, as well as for small and nonstandard fields, and brachytherapy. It focuses primarily on work performed in the last ten years by national laboratories and research institutions and is not restricted to primary standard instruments. The most recent absorbed dose calorimetry review article was published over twenty years ago by Ross and Klassen ( Phys. Med. Biol. 41 1–29), and even then, its scope was limited to water calorimeters. Since the application of calorimetry to the measurement of radiation has a long and often overlooked history, a brief introduction into its origins is provided, along with a summary of some of the landmark research that have shaped the current landscape of absorbed dose calorimeters. Technical descriptions of water and graphite calorimetry are kept general, as these have been detailed extensively in relatively recent review articles (e.g. McEwen and DuSautoy ( Metrologia 46 S59–79) and Seuntjens and Duane ( Metrologia 46 S39–58). The review categorizes calorimeters by the radiation type for which they are applied; from the widely established standards for Co-60 and high-energy x-rays, to the prototype calorimeters used in high-energy electrons and hadron therapy. In each case, focus is placed on the issues and constraints affecting dose measurement in that beam type, and the innovations developed to meet these requirements. For photons, electrons, proton and carbon ion beams, a summary of the ionization chamber beam quality conversion factors (kQ) determined using said calorimeters is also provided. The article closes with a look forward to some of the most promising new techniques and areas of research and speculates about the future clinical role of absorbed dose calorimetry.

This is the first time that water calorimetry has been successfully used to measure electron beam quality conversion factors for energies as low as 6 MeV (R50=2.25 cm).