Fourteen cervical spine motion segments consisting of two adjacent vertebral bodies and their connecting ligaments were tested in shear. Five had intact facet joints, five had bilateral facetectomy of 50% or less, and four had bilateral 70% facetectomy. Three to 5 mm of root could be exposed in the specimens with 50% facetectomy, and 8 to 10 mm in those with 70% facetectomy. Anterior-posterior shear tests were run alternately in compression and distraction. Facetectomy was found to have no effect on compression and distraction stiffness. Failure in the 70% facetectomized specimens was due to fracture of the remaining joint at 159 lbs. In the specimens with 50% facetectomy, a fracture load could not be established since failure of the specimen mounting occurred at 208 lbs, as it did in two of the specimens without facetectomy that were tested to failure. The difference in bone fracture at 159 lbs and mounting failure at 208 lbs is significant at p less than 0.05. Bilateral resection of more than 50% of the facet joint significantly compromises the shear strength of a cervical spine motion segment.

No abstract

No abstract

Articular cartilage is known to have limited ability to heal once injured, and attempts to heal lesions in cartilage have yielded equivocal results. The following experiments were performed to investigate healing in cartilage transplantation of chondrocytes grown in vitro. The knee joint of the New Zealand White rabbit was used as the experimental model. An initial baseline study was made to determine the intrinsic capability of cartilage for healing defects that do not fracture the subchondral plate. A second experiment examined the effects of autologous in vitro grown chondrocytes on the healing rates of these defects. The results were evaluated by qualitative and quantitative light microscopy. In control defects not grafted with chondrocytes, 6 weeks after the initial defect was created, there was little repair. Macroscopic and histological findings were consistent with an osteoarthritic pathology such as synovitis and "cell nests." Macroscopic results from grafted specimens displayed a marked decrease in synovitis and other degenerative changes. Defects which had received transplants had a significant amount of cartilage reconstituted (82%) compared to ungrafted controls (18%). Controls showed a healing rate comparable to that obtained in the initial baseline study.