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A simple, rapid, precise, and accurate method is described for the simultaneous and quantitative determination of conjugated and unconjugated chlorpromazine metabolites in urine. It depends on reduction of sulfoxides to sulfides, and oxidation of sulfides to ion radicals in a solution of Fe+3 (10-3N) in 18N H2SO4. Absorbance is measured at 422, 530, 565, and 700 nm, and concentration of metabolites is calculated by substituting values obtained in appropriate equations. Our data for urines (from schizophrenic men chronically medicated with chlorpromazine) generally agree with those of other workers.

Inosiplex (Isoprinosine), a complex containing hypoxanthine riboside, was administered to 7 men with senile dementia; in 6 it was given for six to nine months, and in 1 for three months. During the first six months, neither further regression nor clinical improvement was noted, although 5 patients gained weight. Originally the study had included 9 patients, but 1 was dropped at one month because of certain diagnostic features and 1 was dropped at one month because the serum uric acid level had risen to 11.3 mg/100 ml. Among the remaining 7 patients, the serum uric acid level in 1 case rose to 10.2 mg/100 mI at six months, but in the other 6 the uric acid values had returned to normal at six months after an earlier slight rise. The urinary excretion of hypoxanthine, xanthine, guanine and uric acid accounted for about 60 per cent of ingested hypoxanthine at one month and 40 per cent at three to seven months. The biochemical data are discussed in relation to some current approaches to the treatment of senile dementia. Inosiplex may prove to have a significant anabolic effect.

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