Endotoxin exposure in early life alters the development of anxiety-like behaviour in the Fischer 344 rat

Walker, Frederick R.; March, James; Hodgson, Deborah M.

doi:10.1016/j.bbr.2004.01.019

Cited by 89 publications

(82 citation statements)

References 27 publications

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“…Exploration of the aversive, open arms of the elevated plus-maze was similar in adolescents and adults; while exploration of the aversive center of the novel open field was lower in peri-but not early adolescents than adults. These data concur with the finding that 4-week old Swiss Webster mice were no different from 8-week olds on the elevated plus-maze at baseline [48] (see also [21]), but not with another report that 7-week, but not 5-week old CD-1 mice showed lesser anxiety-like behavior in this test than adults [34], or with data variously reporting either relatively increased or decreased anxiety-like behavior in adolescents rats in both the elevated plus-maze, light/dark exploration test and the social interaction test [9,13,15,18,25,41,43,51]. Such differences may be due to methodological differences between studies.…”

Section: Discussionmentioning

confidence: 87%

“…For example, adolescent rats have been found to exhibit either lesser, greater or normal levels of anxiety-like behavior in various behavioral assays as compared to adults [9,13,15,18,25,41,43,51]. In addition, a number of studies have shown that conditioned fear responses to footshock in rats emerges in the early adolescent period (reviewed in [6,23,24,47]).…”

Section: Introductionmentioning

confidence: 99%

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Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice

Hefner¹,

Holmes²

2007

Behavioural Brain Research

163

113

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Adolescence is characterized by behavioral traits such as emotional lability and impulsivity that are associated with increased vulnerability to affective illness and addictions. Research in rodents has found that adolescent rats and mice differ from adults on measures of anxiety-like behavior, noveltyseeking and stress-responsivity. The present study sought to extend these data by evaluating fear-, anxiety-and depression-related behaviors in male C57BL/6J mice aged four (early adolescent), six (peri-adolescent) or eight (early adult) weeks of age. Age-groups were compared on: Pavlovian fear conditioning and extinction, anxiety-like behavior and exploratory locomotion (using elevated plusmaze and novel open field), and depression-related behavior (via forced swim test). Results showed that early adolescent mice exhibited enhanced fear conditioning, but extinguished at a similar rate as adults. There were no major differences in anxiety-like behavior across age-groups, although early adolescent and peri-adolescent mice exhibited less exploratory locomotion than adults. Depressionrelated immobility behavior in the forced swim test was lower in early adolescents than adult mice across three test exposures. Present findings in the C57BL/6J inbred strain add to growing evidence of changes in rodent fear-and stress-related behaviors across the developmental transition from juvenility through adulthood. Understanding the neural basis of these ontogenic changes could provide insight into factors could provide insight into the pathogenesis and treatment of affective disorders that have their origins in adolescence.

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Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice

Hefner¹,

Holmes²

2007

Behavioural Brain Research

163

113

View full text Add to dashboard Cite

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“…Some alterations in performance in the elevated plus maze have been observed with a neonatal LPS challenge in investigations from other laboratories. However, at least one of these studies used the hypersensitive Fischer 344 rat (Walker et al, 2004), indicating a possible strain difference on behavioral consequences of neonatal LPS exposure. Also, in each of these studies, the LPS was delivered at earlier time points P3 and/or P5 (Walker et al, 2004;Breivik et al, 2002;Anseloni et al, 2005).…”

Section: Lps Does Not Significantly Alter Adult Behavior In the Elevamentioning

confidence: 99%

“…One major factor in this may be the timing of the early challenge. We have previously shown that LPS given at P14 does not affect basal exploration of the elevated plus maze, an assessment of activity and anxiety; however, two studies which involved an endotoxin exposure at earlier time points have demonstrated effects on plus maze responses in adults (Breivik et al, 2002;Walker et al, 2004). Thus, we also assessed activity and anxiety responses in the elevated plus maze.…”

Section: Introductionmentioning

confidence: 97%

“…Early-life manipulations such as a neuroimmune challenge have been shown in some studies to affect activity and anxiety responses to mildly stressful situations in adulthood; however, there are some discrepancies between the findings (Walker et al, 2004;Breivik et al, 2002;Spencer et al, 2005). One major factor in this may be the timing of the early challenge.…”

Section: Introductionmentioning

confidence: 99%

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Early-Life Immune Challenge: Defining a Critical Window for Effects on Adult Responses to Immune Challenge

Spencer

Martin

Mouihate

et al. 2006

Neuropsychopharmacol

100

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Many aspects of mammalian physiology are functionally immature at birth and continue to develop throughout at least the first few weeks of life. Animals are therefore vulnerable during this time to environmental influences such as stress and challenges to the immune system that may permanently affect adult function. The adult immune system is uniquely sensitive to immune challenges encountered during the neonatal period, but it is unknown where the critical window for this programming lies. We subjected male Sprague-Dawley rats at postnatal day (P)7, P14, P21, and P28 to either a saline or lipopolysaccharide (LPS) injection and examined them in adulthood for differences in responses to a further LPS injection. Adult febrile and cyclooxygenase-2 responses to LPS were attenuated in rats given LPS at P14 and P21, but not in those treated at P7 or P28, while P7-LPS rats displayed lower adult body weights than those treated at other times. P28-LPS rats also tended to display enhanced anxiety in the elevated plus maze. In further experiments, we examined maternal-pup interactions, looking at the mothers' preference in two pup-retrieval tasks, and found no differences in maternal attention to LPS-treated pups. We therefore demonstrate a 'critical window' for the effects of a neonatal immune challenge on adult febrile responses to inflammation and suggest that there are other critical time points during development for the programming of adult physiology. We also show that the neonatal LPS effects on the adult immune system are not likely due to overt differences in maternal attention.

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Predicting Health: The Role of the Early‐Life Environment

Sominsky¹,

Walker²,

Hodgson³

2013

The Wiley‐Blackwell Handbook of Psychoneuroimmunology

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Endotoxin exposure in early life alters the development of anxiety-like behaviour in the Fischer 344 rat

Cited by 89 publications

References 27 publications

Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice

Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice

Early-Life Immune Challenge: Defining a Critical Window for Effects on Adult Responses to Immune Challenge

Predicting Health: The Role of the Early‐Life Environment

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