daily intake of approximately 120 nig and equal to at least 500 mg per kilo of body weight.The sulfanilamide had no apparent effect on the Bartowlla rtluris. All 15 of the treated rats gave positive blood smears, taken on the third to fifth day after being infected, and 10 died within 12 days. These were practically the same results as obtained in 15 untreated controls where 14 gave positive blood smears and 8 died. The effectiveness of sulfanilan?ide was further tested by adding 1% to the solution of physiological saline and sodium citrate just described for Group A. The donor blood was added to this 1% mixture and allowed to stand 10 minutes, then injected intraabdominally into the splenectomized recipient rats. The results again failed to show any beneficial effect from sulfanilaniide; 13 of the 15 rats in this group showed positive blood smears and all were dead within 12 days. The toxicity of the sulfanilamide may have contributed to the high mortality in this group as compared to the controls. In all groups the Bartonella murk bodies disappeared rapidly from the blood and were usually not found after the fifth day, even though the symptoms were so severe that the rats continued in an emaciated condition for several more days, After the twelfth day, few died3Splenectoniized rats infected with Burtonella murk were treated with sulfanilamide in doses of 500 nig per kilo of body weight. A study of 30 rats thus treated showed that the treatment had no detectable effect on Bartonelln miris. The toxicity of the sulfanilamide seemed to be a factor contributing to the mortality.Suwnavy.
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