The Vital Importance of Salivary Glands to Newborn Rats

Plagge, James C.

doi:10.1152/ajplegacy.1938.124.3.612

Cited by 12 publications

(6 citation statements)

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“…Their observations agreed with the view of Krzywanek and Brliggemann that the tongue and mouth of the suckling ruminant acts on the teat like the hand of the milker; in short, the milk is trapped in the teat cistern by compressing the base of the teat and is then expressed through the teat canal at the tip of the teat. If, however, the litter is reduced to three pups or less the desalivated pups can survive, which suggests that the saliva is necessary to ensure adequate fixation to the nipple in the face of peer competition rather than that suction is necessary to extract milk from the nipple (Plagge, 1938;Epstein et aI., 1970). 4.30).…”

Section: Mechanics Of Sucklingmentioning

confidence: 99%

Lactation

Cowie

Forsyth

Hart

1980

Hormonal Control of Lactation

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Section: Mechanics Of Sucklingmentioning

confidence: 99%

Lactation

Cowie

Forsyth

Hart

1980

Hormonal Control of Lactation

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“…Sialoadenectomy has been reported to impair growth, especially in young rats (Plagge, 1938;Bixler et al, 1955;Shaw and Wolman, 1958;Haldi and Wynn, 1963). Plagge (1938) and Bixler et al (1955) suggested that this impairment might be attributed to a low food intake associated with some mechanical factors in the feeding process caused by Sx.…”

Section: Discussionmentioning

confidence: 99%

“…Plagge (1938) and Bixler et al (1955) suggested that this impairment might be attributed to a low food intake associated with some mechanical factors in the feeding process caused by Sx. However, Haldi and Wynn (1963) showed that, even when animals were fed an identical amount of food by a stomach tube, sialoadenectomized rats gained less weight than their controls.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Cheng et al (1982) reported that sialoadenectomy (Sx) in lk,lc hypertensive rats caused a substantial lowering of BP, which they attributed to the elimination of the tonin-rich submandibular gland. However, they did not report the rats' body weight, which, secondary to Sx, would be affected by a decrease in food intake (Plagge, 1938), and which, in turn, could affect BP. Nevertheless, these studies suggested an important role of tonin in the pathogenesis of lk,lc hypertension.…”

mentioning

confidence: 99%

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Lack of evidence for the participation of tonin in the pathogenesis of one-kidney, one-clip renovascular hypertension.

Seto

Rabito

Scicli

et al. 1984

Circulation Research

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SUMMARY. It has been reported that immunization against tonin normalizes blood pressure, and that sialoadenectomy, during which the tonin-rich salivary glands are removed, decreases blood pressure in one-kidney, one-clip hypertension. To investigate the role of tonin on this form of hypertension further, we actively immunized one-kidney, one-clip hypertensive rabbits with tonin and measured both the blood pressure response and the titer of antibodies raised against tonin. In addition, because sialoadenectomy may alter food intake, we assessed the effect of sialoadenectomy on the blood pressure of one-kidney, one-clip hypertensive rats fed a liquid diet to facilitate eating. After immunization, all rabbits developed antitonin-antibody titers ranging from 1:300 to 1:56,000. However, in none of the rabbits did the blood pressure decrease significantly (114 ± 3 mm Hg before immunization; 129 ± 6 mm Hg at 16 weeks after immunization). In onekidney, one-clip hypertensive rats, sialoadenectomy did not lower blood pressure (179 ± 5 mm Hg before sialoadenectomy; 202 ± 9 mm Hg 3 weeks after sialoadenectomy). Neither blood pressure nor body weight differed between sialoadenectomy and sham-sialoadenectomy onekidney, one-clip hypertensive rats (n = 6). In conclusion, neither active immunization against tonin in one-kidney, one-clip hypertensive rabbits nor sialoadenectomy in one-kidney, one-clip hypertensive rats significantly reduced established hypertension. These results do not support the hypothesis that tonin is involved in the pathogenesis of one-kidney, one-clip hypertension in these animal models. (Circ Res 55: 580-584, 1984)

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“…Rats deprived of submandibular-sublingual saliva before the 10th day of age die of starvation, but they are able to suckle effectively if the submandibular-sublingual ablation is not done until the 13th day or later, when the development of the parotid glands has begun (Plagge 1938). However, effective suckling can be restored to the desalivated pups by periodic treatment of their lips with vaseline (Epstein et al 1970).…”

mentioning

confidence: 99%

Fluid and Protein Secretion by the Submandibular Glands of Weanling Rats in Response to Cholinergic and Peptidergic Agonists at Various Doses

Baba

Taniguchi

Motokawa

et al. 1995

Journal of Pharmacy and Pharmacology

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Fluid and protein secretion by the submandibular glands of 25-day-old rats were examined and compared in response to three cholinergic and four peptidergic sialogogues at various doses. All cholinergic and peptidergic agonists used were potent sialogogues for the submandibular glands of the weanling rats over the wide range of doses used. The cholinergic agonists, bethanechol and methacholine and the peptidergic agonists, substance P, substance PTyr8 and eledoisin-related peptide used intravenously, acted similarly to each other on the submandibular glands of the rats, late in the natural weaning period, but carbachol and physalaemin had slightly different effects. Of the peptidergic agonists, physalaemin was the most potent sialogogue among four tachykinins tested at the low dose. The types of protein secreted by the submandibular glands of the weanling rats in response to all sialogogues used here were typical of the beta-type. These results indicate that all agonists used could mainly stimulate the acinar cells of the submandibular glands of the weanling rats which have already fully developed functionally at this time.

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The Vital Importance of Salivary Glands to Newborn Rats

Cited by 12 publications

References 0 publications

Lactation

Lactation

Lack of evidence for the participation of tonin in the pathogenesis of one-kidney, one-clip renovascular hypertension.

Fluid and Protein Secretion by the Submandibular Glands of Weanling Rats in Response to Cholinergic and Peptidergic Agonists at Various Doses

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