Objective: To evaluate the anticonvulsant activity of Nifedipine against MES induced seizures.Methods: The study was induced by techno electroconvulsometer. The animals were treated with Nifedipine (100 μg/100 g i. p. and 200 μg/100 g i. p.) and MES was induced 2 h after the administration of the drug, and duration of various phases was noted. Duration of THLE was taken as an index for antiepileptic activity.Results: Nifedipine when administered in a dose of 100 μg/100 g ip, did not produce any changes in any phases of the MES induced seizure. But in a dose of 200 μg/100 g ip, it significantly reduced the duration of THLE.Conclusion: Nifedipine has a significant action against MES induced seizures suggesting an important role of CCBs as future, promising antiepileptic drug.
The most effective renewable energy in the future among energy. Using photovoltaic (PV) panels is the most effective approach to utilize solar energy for electrical power. The photovoltaic panel that uses solar energy has non-linear voltage-current and voltage-control properties. The control yield from the solar-powered PV board is highest at a certain voltage point. The maximum power point voltage is the voltage at which the PV board produces the most power. The construction of the solar-powered PV board and a description of its features have been presented. In order to acquire the highest control point voltage, the difference between the real Maximum Power Point Tracking (MPPT) voltage and the MPPT voltage deduced from the Artificial Neural Network (ANN) arrangement is displayed, and it is successfully accepted. The result appears to be an exact match for the accuracy of ANN. The PV board's highest control point can be successfully and accurately tracked using the ANN display that was obtained. From the various results obtained, it becomes obvious that the suggested computation proves to be considerably simpler in following the PV board's most extreme control point. The reaction time is drastically reduced when the proposed control approach is used since the PV voltage closely tracks the highest control point voltage. Additionally, the proposed strategy's precision is incredibly logical. In every irradiance and temperature scenario, the control framework performs well.
Background: To evaluate the anticonvulsant activity of Nimodipine alone and in combination with Phenytoin, in MES induced seizures.Methods: The study was conducted in mice and MES seizure was induced by Techno electroconvulsometer. In first part of study, animals were treated with Nimodipine (20mg/kg i.p. and 40mg/kg i.p.) and Phenytoin (0.5 mg/100g i.p. and 1.0mg/100g i.p.), MES was induced and durations of various phases were noted. Duration of Tonic hind limb extension (THLE) was taken as index for antiepileptic activity. In second part, the animals were treated with combination of sub effective doses of Nimodipine (20mg/kg i.p.) and Phenytoin (0.5mg/100g i.p.), MES was induced and durations of various phases were noted.Results: Nimodipine produced significant antiepileptic activity, in dose dependent manner. Phenytoin produced significant antiepileptic effect in dose of 1.0mg/100g but failed to produce any such effect in dose of 0.5mg/100g, when administered alone. But when sub effective doses.Of Nimodipine and Phenytoin were combined, a synergistic effect was seen.Conclusions: Nimodipine possess significant antiepileptic activity, alone, as well as it potentiates the antiepileptic effect of Phenytoin, suggesting the novel application of already proven safe and efficacious calcium channel blockers.
Objective: To evaluate the anticonvulsant activity of Nimodipine alone and in combination with Phenytoin, in MES induced seizures.Methods: The study was conducted in mice and MES seizure was induced by Techno electro-convulsometer. In the first part of the study, animals were treated with Nimodipine (20 mg/kg i. p. and 40 mg/kg i. p.) and Phenytoin (0.5 mg/100g i. p. and 1.0 mg/100g i. p.), MES was induced and durations of various phases were noted. Duration of Tonic hindlimb extension (THLE) was taken as an index for antiepileptic activity. In the second part, the animals were treated with a combination of sub effective doses of Nimodipine (20 mg/kg i. p.) and Phenytoin (0.5 mg/100g i. p.), MES was induced and durations of various phases were noted.Results: Nimodipine produced significant antiepileptic activity, in a dose-dependent manner. Phenytoin produced a significant antiepileptic effect in dose of 1.0 mg/100g, but failed to produce any such effect in a dose of 0.5 mg/100g, when administered alone. But when sub-effective doses. Of Nimodipine and Phenytoin were combined, a synergistic effect was seen.Conclusion: Nimodipine posses significant antiepileptic activity, alone, as well as it potentiates the antiepileptic effect of Phenytoin, suggesting the novel application of already proven safe and efficacious calcium channel blockers.
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