Anticonvulsive effects of nifedipine and flunarizine on maximal electroshock seizures induced seizures

Raina, Jain; Bankey, Naveen; Jain, Ashish

doi:10.5455/njppp.2018.8.0519029052018

Cited by 2 publications

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“…The predicted repositioned drug flunarizine is a calcium channel blocker, also observed in our docking study. Due to its calcium blocker activity, various researchers have tried to check its anti-epileptic properties in the developed epilepsy model and got a significant response [ 42 - 44 ]. Antidepressants are used as combinational therapy options in epileptic patients observing depression-like symptoms.…”

Section: Discussionmentioning

confidence: 99%

Drug repositioning for idiopathic epilepsy using gene expression signature data

Kumar¹

2022

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Epilepsy is one of the most common neurological disorders, affecting millions of patients with a substantial economic and human burden. About 30-40% of epileptic patients remain un-treated after the therapeutic option. Genetic or idiopathic epilepsy count about 40% of total epilepsy patients, showing a maximum percentage for drug-resistant epilepsy. Since the last century basic approach to understanding disease progression and drug discovery has been through the prism, exploring all possible causes and treatment options. Here we report about the gene expression-based drug repositioning study for epilepsy. Epilepsy gene expression data was retrieved from the Gene Expression Omnibus database, while drugs-associated gene expression data was retrieved from the Connectivity map (CMAP). The study predicted309 drug compounds which can alter genetic epilepsy-mediated gene signature using an in-house developed R-script. These compounds were docked against identified epilepsy targets– Voltage-gated sodium channel subunit a2 (Nav1.2); GABA receptor a1-b1; and Voltage-gated calcium channel a1G (Cav3.1)using Carbamazepine, Clonazepam, and Pregabalin as standard drugs, respectively. Twenty-one predicted drug compounds showed better binding affinity than respective standards against the selected epileptic receptors. Among these drug compounds, Ergocalciferol, Oxaprozin, Flunarizine, Triprolidine and Cyproheptadine have been previously reported for anti-epileptic activities and can be potential hits to target idiopathic epilepsy.

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Section: Discussionmentioning

confidence: 99%

Drug repositioning for idiopathic epilepsy using gene expression signature data

Kumar¹

2022

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“…Regulation of calcium homeostasis can be regulated by voltagegated calcium channels which are categorized into groups such as high-voltage activated calcium channels (L-type) and low-voltage activated calcium channels (T-type). Both L-type and T-type calcium channels are found in CNS and have been developed to treat various neurological diseases [13][14][15]. Nimodipine (NIM), an L-type calcium channel blocker inhibits the calcium influx through voltage sensitive L-type calcium channels and promotes the cerebral flow.…”

Section: Introductionmentioning

confidence: 99%

Biochemical and ultrastructural alterations in the brain of mice induced by aqueous leaf extract of a medicinal plant, Lantana camara L. and its amelioration by nimodipine and flunarizine

Ashalata¹,

Sengupta²,

Bawari³

2021

J App Biol Biotech

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Lantana camara L., a plant used as an ethnomedicine, is considered to be toxic. In this context, evaluation of neurotoxic effect of L. camara was studied. Here, experimental mice were orally administered with an aqueous leaf extract of L. camara (AQLC) (500 mg/kg body weight) for 14 days. Biochemical assays, acetylcholinesterase (AChE) activity as well as microscopic studies were performed to assess its neurotoxic effects. Administration (per oral) of AQLC in mice induced significant oxidative damage in the brain cortex and cerebellum as evidenced by increased lipid peroxidation, protein carbonylation, and also the activity of AChE. This was associated with declining of the endogenous antioxidants such as superoxide dismutase and glutathione peroxidase. Co-treatment of calcium channel blockers, nimodipine (20 mg/kg body weight) and flunarizine (10 mg/kg body weight) along with the aqueous extract of L. camara were seemed to ameliorate the neurotoxic effect caused by AQLC. Furthermore, disintegration in the ultrastructure of brain cortex induced by L. camara was restored by treating calcium channel blockers. Altogether, the findings of this study concluded that the AQLC has potential neurotoxic effect in mice.

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Anticonvulsive effects of nifedipine and flunarizine on maximal electroshock seizures induced seizures

Cited by 2 publications

References 0 publications

Drug repositioning for idiopathic epilepsy using gene expression signature data

Drug repositioning for idiopathic epilepsy using gene expression signature data

Biochemical and ultrastructural alterations in the brain of mice induced by aqueous leaf extract of a medicinal plant, Lantana camara L. and its amelioration by nimodipine and flunarizine

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